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The recombinant YFP (Yellow Fluorescent Protein) is expressed and purified from transformed E. coli using a method that ensures high purity and maximal YFP fluorescence. Endotoxin has been removed,...

3991 | YFP Antibody DataSheet

YH239-EE is potent p53-MDM2 interaction inhibitor that induces cell cycle arrest leading to potential apoptosis by p53 activation and downstream target in AML cells with p53 mutationYH239-EE is...

YK-3-237 is a sirtuin 1(SIRT1) activator. It activates SIRT1 in a concentration-dependent manner and reduces acetylation of wild-type and mutant p53 in a SIRT1-dependent manner YK-3-237 inhibits cell...

YK-4-279 is an Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s...

YK-11 is a synthetic, steroidal selective androgen receptor modulator (SARM). The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone (DHT) in...

YKL-05-099 | B3387Description: YKL-05-099 is an inhibitor of the salt-inducible kinase (SIK1 and SIK3; IC50s: 10 and 30 nM, respectively). It displays less potency towards SIK2 (IC50 = 40 nM)...

YM-254890 | B3393Description: YM-254890 is a cyclic depsipeptide that acts as a Gα-protein inhibitor. It potently inhibits Gq/11 heterotrimeric G protein signaling. Inhibits ATP/UTP-induced Ca2+...

YM-90709 is a selective inhibitor of interleukin-5 (IL-5). YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15...

YM155 is a novel small molecule survivin suppressant; suppresses the expression of surviving and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L.YM155 is a novel small molecule...

Cell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC50 = 33 nM). It inhibits p110α at higher concentration (IC50 = 3 µM). It reversibly impairs endosomal...

Yoda -1 is a synthetic small molecule that acts as an agonist for both human and mouse Piezo1. Characterization of Yoda1 in artificial droplet lipid bilayers shows that Yoda1 activates purified...

YU238259 is a potent inhibitor of Homology-Dependent DNA Repair (HDR). YU238259 displays potent synthetic lethality in the setting of DNA damage response and DNA repair defects. YU238259 specifically...

YW3-56 is an inhibitor of protein arginine deiminases PAD2 and PAD4 which convert protein arginine residues to citrulline. The IC₅₀ for inhibition of PAD4 and PAD2 is about 1–2 μM and 0.5–1 μM...

Z-AEVD-FMK is a synthetic peptide inhibitor that inhibits caspase-10 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies...

A synthetic peptide that irreversibly inhibits caspase-12 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is...

A synthetic peptide that irreversibly inhibits activity of DEVD-dependent caspases (e.g., caspase-3 and caspase-7) and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell...

Cell-permeable. A useful negative control for FMK-labeled caspase inhibitors. Also, an irreversible inhibitor of cathepsins B, L, and S, and likely cathepsin H, as well as cruzain and papain.Z-FA-FMK...

A synthetic peptide that irreversibly inhibits FLICE and related protease/caspase activity and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is...

A synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on...

A synthetic peptide that irreversibly inhibits activity of LEVD-dependent caspases (e.g., caspase-4). The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be...

A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can...

A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in...

VEID is the specific recognition sequence for caspase-6/Mch2. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant...

Z-VRPR-FMK is selective and irreversible MALT-1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor that inhibits NF- κB dependent gene expression affecting the growth,...

A synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in...

Zalcitabine is an antiviral pyrimidine nucleoside analog effective against HIV replication. In cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV...

Zanamivir is a potent and selective inhibitor of influenza A and B virus neuraminidases with IC₅₀ values of 0.95 nM and 2.7 nM, respectively. It interacts with a group of amino acids in the active...

Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor; displaysmuch more restricted off-target activities against a panel of kinases, including ITK, compared with Ibrutinib...

ZAP70 is a non-receptor protein tyrosine kinase (part of the Syk/Zap70 family) that is involved in signaling by the T-cell antigen receptor (TCR). Ligation of the TCR/CD3 receptor in Jurkat T-cells...

Cell-permeable. A selective inhibitor of cGMP-specific phosphodiesterase (PDE V) (IC₅₀ = 0.45 µM). Inhibits PDE IX only at higher concentrations (IC₅₀ = 35 µM).Zaprinast is a selective inhibitor of...

3791 | ZBTB7/Pokemon Antibody DataSheet

Cell-permeable. A selective CDc42 GTPase inhibitor. It specifically targets Cdc42-ITSN interaction and inhibits Cdc42-mediated cellular processes; could be a valuable tool to explore Cdc42’s...

E4276 | Zearalenone ZEN Elisa Kit DataSheet

Zebularine is a potent inhibitor of cytidine deaminase and DNA methylation; inhjbits DNA methylation by forming a covalent complex with DNA methyltransferases (DNMTs). Displays antitumor properties...

Zibotentan is an orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby...

A potent and reversible 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis (IC₅₀ values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively).Zileuton is a potent and...

K428 | Zinc Assay Kit Fluorometric DataSheet

K387 | Zinc Colorimetric Assay Kit DataSheet

ZINC00881524 is a potent ROCK (Rho Kinase) inhibitor.ZINC00881524 is a potent ROCK (Rho Kinase) inhibitor.B1840 | ZINC00881524 DataSheetAlternate Name/Synonyms:...

Zinpyr-1 is a membrane-permeable fluorophore suitable for the fluorometric detection of free Zn²⁺. In living cells, Zinpyr-1 mainly stains the Golgi or a Golgi-associated vesicle.Zinpyr-1 is a...

ZK-756326 dihydrochloride | B3390Description: ZK-756326 is a non-peptide agonist of the CC chemokine receptor CCR8. It inhibits binding of CCL1 to human CCR8 (IC50 = 1.8 µM) and induces Gai-mediated...

ZLN005 is a small molecule transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). It stimulates the expression of PGC-1α and downstream genes in skeletal...

ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC₅₀s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively. Inhibits dephosphorylation of AMPK Thr-172 by...

Cell-permeable. A potent, selective and ATP-competitive inhibitor of c-Raf in vitro (IC₅₀ = 70 nM for inhibition of human c-Raf). Displays 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38...

Cell-permeable. A selective, ATP-competitive inhibitor of Aurora B kinase in vitro (IC₅₀ values are 50 nM, 250 nM and 1 μM for Aurora B, C and A kinases respectively). Selective over a range of other...

ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. It inhibits the activity of KDR and Flt VEGF receptors with IC₅₀ values of 100 nM and 2 μM,...

ZnAF-2 DA is a cell-permeable derivative of ZnAF-2. A fluorescent reagent suitable for the fluorimetric detection of Zn²⁺ (after esterase hydrolysis).ZnAF-2 DA is a cell-permeable derivative of...

ZnAF-2, 6-iso-, is a cell-impermeable compound that acts as a high-affinity Zn²⁺-specific fluorescent probe (Kd = 2.7 nM). It shows low basal fluorescence and the fluorescence intensity increases...

5406 | ZNF521 Antibody (NT) DataSheet

Zoledronic acid is a third-generation bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption. It displays high...

Zonisamide is a broad-spectrum sulfonamide derivative with an anticonvulsant property. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing...

Zosuquidar is a potent P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Zosuquidar binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). Restores...

Zotarolimus is a semi-synthetic derivative of Sirolimus (Cat. No. 1568) that acts as an immunosuppressant. Zotarolimus displays meachanism similar to sirolimus in having high-affinity binding to the...

ZSTK474 is a reversible, potent and specific inhibitor of phosphoinositide 3-kinase (PI3K) isoforms ((IC₅₀s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). More effective than LY 294,002 in...

ZXX2-77 is a benzenesulfonanilide derivative that inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. It shows more potent analgesic activity than aspirin at 30 mg/kg by po. It can be used as a...

α-Cyano-4-hydroxycinnamate (4-CIN) is a monocarboxylate transporter (MCT) inhibitor. Displays antitumor and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and...

α-GalCer is a specific ligand for human and mouse natural killer T (NKT) cells; exhibits potent anti-tumor activity with murine in vivo experiments including subcutaneous implanted model and...

α-Mangostin, a naturally occurring xanthone, displays both fast-binding and slow-binding inhibitions to FAS in vitro. It inhibits FAS overall reaction with an IC50 value of 5.54 μM noncompetitively...

Potent and selective inhibitor of CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50 = 500, 60, 6, and 5 nM respectively). Can activate CYP3A4 (Kd = 7.4 µM).Potent and selective inhibitor of CYP19...

α-Tocopheryl succinate is an analog of α-Tocopherol (Vitamin E) with unique biological properties. It is the most effective form of Vitamin E in inducing differentiation, inhibition of proliferation...

β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin, one of the main constituents of licorice. It inhibits 15-PGDH (15-hydroxyprostaglandin dehydrogenase) leading to increased prostaglandin...

Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin (Cat. No. 1039), β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in...

β-Nicotinamide adenine dinucleotide sodium is the most common form of NAD. NAD can be reduced to NADH during coupling with reactions which oxidize various organic substrates. NADH then passes to the...

Nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances...

3939BP | β3-AR Blocking Peptide DataSheetAntibody Target: β3-ARAccession #: NP_037240.1Gene ID: 25645Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

K2029 | 1,5-Anhydroglucitol Assay Kit (Colorimetric) DataSheet1,5-Anhydroglucitol (1,5-AG) is a metabolically inactive deoxy analogue of glucose that is present in most grains and meats. It is well...

E4900 | 11-Dehydrothromboxane B2 ELISA Kit DataSheet11-Dehydrothromboxane B2 (11dhTxB2 or 11-dehydro-TxB2) is a stable metabolite of Thromboxane A2 (TxA2). TxA2 is a prothrombotic agent capable of...

Fas-associating death domain containing protein (FADD), also known as mediator of receptor induced toxicity (MORT1), is a 23 kDa cytosolic protein with an apparent molecular weight of 28 kDa on...

K2051 | 20S Immunoproteasome Activity Assay Kit (Fluorometric) DataSheetProteasome mediated protein degradation is one of the major pathways for the degradation of damaged, misfolded or aggregated...

CD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand (CD40L), a cytokine expressed on...

K175 | 3’ to 5’ Exonuclease Activity Assay (Fluorometric) DataSheetExonucleases remove a single nucleotide or an oligonucleotide at the 5’ or 3’ end. Exonuclease, such as Three Prime Repair...

Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). PRMT6 catalyzes the sequential transfer of a methyl group...

K2032 | 3D Culture HTS Cell Viability Assay Kit (Colorimetric) DataSheetThree-dimensional (3D) cell cultures are artificially-created environments, where cells are allowed to grow or interact with...

TCTN1 belongs to the Tectonic protein family that regulate Hedgehog (Hh) pathway. During neural tube development, TCTN1 is required for the formation of most ventral cell types and for full Hh...

E4790 | 6-keto-PGF1 α ELISA Kit DataSheet6-keto-PGF1α is a stable hydrolysis product of prostacyclin. PGI2 has autocoid functions that include platelet aggregation, inhibition of vasoconstrictor...

Hsp27 exhibits a chaperone-like activity by serving as a site where unfolding proteins may bind until ATP and Hsp70-dependent refolding can occur. Hsp27 is believed to protect cells by enhancing...

E4789 | 8-epi-PGF2α ELISA Kit DataSheetF2αisoprostanes are a family of prostaglandin F2αlike compounds that are formed by freeαradicalαcatalyzed peroxidation of arachidonic acid. Several...

AMPK beta-1 chain is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK...

E4965 | ACCPA (Human) ELISA Kit DataSheetAnti-cyclic citrullinated peptide antibodies (ACCPA) are autoantibodies that target citrullinated peptides or proteins. Citrullination or deimination is a...

AMPK? (PRKAA1) belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all...

E4966 | ACCPA (Mouse) ELISA Kit DataSheetAnti-cyclic citrullinated peptide antibodies (ACCPA) are autoantibodies that target citrullinated peptides or proteins. Citrullination or deimination is a...

AMPK2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an...

K2001 | ACE1 Colorimetric Activity Assay Kit DataSheetAngiotensin-I-converting enzyme (ACE1) is a peptidyl dipeptidase that catalyzes the conversion of decapeptide angiotensin I to octapeptide...

HNF4A is a nuclear transcription factor which binds DNA as a homodimer. This protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor...

K719 | ACE1 Inhibitor Screening Kit (Colorimetric) DataSheetAngiotensin-I-converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of decapeptide angiotensin I to octapeptide...

K184 | Acyl-CoA Synthetase Fluorometric Assay Kit DataSheetAcyl-CoA Synthetase (ACS) also known as Acyl-CoA ligase, is a ubiquitous enzyme that catalyzes the reaction of free fatty acids and Coenzyme...

Caspase family of cysteine proteases plays a key role in apoptosis. Caspase-9 is one of the most important caspases among the caspase family members. Upon induction of apoptosis, cytochrome c...

ACADL belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes. This protein is involved in fatty acid and branched chain amino acid metabolism. ACADL catalyzes...

E5036 | ADAM12 (Human) ELISA Kit DataSheetDisintegrin and metalloproteinase domain-containing protein12 also known as ADAM12 belongs to the ADAM (a disintegrin and metalloprotease) protein family...

K1473 | Adeno-Associated Virus qPCR Quantification Kit DataSheet’s Adeno-Associated Virus qPCR Quantification Kit is used for the quantification of adeno-associated Virus. This kit employs a quick...

PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many...

K1459 | Adenovirus Purification Kit DataSheet’s Adenovirus Purification Kit is used to capture, concentrate and store adenoviruses using magnetic beads. Viruses are important gene delivery tools,...

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism,...

E4971 | AIRE (Human) ELISA Kit DataSheetAutoimmune regulator (AIRE) is a key transcription factor that is expressed in the epithelial cells of the thymic medulla (mTECs). Besides the thymus, AIRE is...

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of...

Short/branched chain acyl-CoA dehydrogenase(ACADSB) belongs to the acyl-CoA dehydrogenase family of enzymes catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or...

E4927 | AKR1C3 (Human) ELISA Kit DataSheetAldo-keto reductase 1C3 (AKR1C3) is a member of the aldo-keto reductase protein superfamily. It is primarily expressed in the endocrine organs such as the...

E5029 | ALCAM/CD166 (Human) ELISA Kit DataSheetALCAM/CD166 antigen is a 100-105 kDa type I transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins, which is also...

Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8...