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AKT3 is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are...

K2011 | Aldehyde Dehydrogenase 2 Inhibitor Screening Kit (Fluorometric) DataSheetAldehyde Dehydrogenase 2 (ALDH2), mitochondrial is a member of the ALDH superfamily that participates in multiple...

K2060 | Aldehyde Dehydrogenase 3A1 Inhibitor Screening Kit (F) DataSheetAldehyde Dehydrogenases (ALDHs; EC 1.2.1.3) are oxidizing enzymes that play an important, anti-oxidative role by oxidizing...

Survivin is a newly described apoptosis inhibitor that is expressed in many human cancers, but undetectable in terminally differentiated adult tissues. It has been shown that recombinant expression...

K369 | Aldose Reductase Activity Kit (Colorimetric) DataSheetAldose Reductase (Aldehyde Reductase; AR; ALR2; EC 1.1.1.21), a member of the aldo-keto reductase superfamily, catalyzes the...

NANOG is a transcription regulator involved with inner cell mass and embryonic stem (ES) cell proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation...

K174 | Aldose Reductase Inhibitor Screening Kit (Colorimetric) DataSheetAldose Reductase (aldehyde reductase; AR; ALR2; EC 1.1.1.21), a member of the aldo-keto reductase superfamily, catalyzes the...

SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The protein may act as...

E4342 | Aldosterone ELISA Kit DataSheetAldosterone controls the sodium-potassium balance through the unidirectional salt reabsorption in a variety of tissues and glands. Synthesized from cholesterol...

AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an...

K2035 | Alkaline Phosphatase Staining Kit DataSheetThe Alkaline Phosphatase (AP) Staining Kit provides a quick and easy method to stain Alkaline Phosphatase in pluripotent stem cells. It is based on...

Survivin is a newly described apoptosis inhibitor that is expressed in many human cancers, but undetectable in terminally differentiated adult tissues. It has been shown that recombinant expression...

E4985 | ALOX15 (Human) ELISA Kit DataSheetArachidonate 15-lipoxygenase (ALOX15) is a non-heme iron-containing dioxygenase enzyme that plays a critical role in the metabolism of polyunsaturated fatty...

PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis...

E4822 | Alpha 1-Antitrypsin (Human) ELISA Kit DataSheetAlpha 1-Antitrypsin is an inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and...

Cathepsin L is a normal lysosomal cysteine endoproteases that is expressed in all cells. The latent 39 kDa pro-Cathepsin L must be processed by cleavage of the 96 amino acid pro-peptide, to generate...

E4823 | Alpha 1-Antitrypsin (Rat) ELISA Kit DataSheetAlpha 1-Antitrypsin is an inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and...

Signaling lymphocytic activation molecule (SLAM/CD150) is expressed at hematopoietic tissue, such as memory T-cells, as well as at immature thymocytes. It has high-affinity self-ligand ability and...

E4797 | Alpha Crosslaps (αCTx) (Human) ELISA Kit DataSheetCrossLaps (CTx) peptide [Glu-Lys-Ala-His-Asp-Gly-Gly-Arg], a part of the C-telopeptide of the alpha 1-chain of type I collagen of bone, is...

Human p21-GTPase-activated protein kinase 1 (PAK1) is a functional homolog of STE20 of Saccharomyces cerevisiae. PAK1 is a downstream effector of the Rho-family small GTPases Rac and Cdc42. A...

E4783 | Alpha-1 Acid Glycoprotein 1 (Human) ELISA Kit DataSheetAlpha 1 acid glycoprotein (AGP1), also known as orosomucoid, is an acute phase protein produced in liver cells and found at high levels...

TLR4 (Toll-like receptor 4) is a mammalain homologue of the Drosophila toll protein. The human TLR4 is a type-1 transmembrane protein containing 799 amino acid residues. The extracellular domain has...

E4784 | Alpha-1 Acid Glycoprotein 1 (Mouse) ELISA Kit DataSheetAlpha 1 acid glycoprotein (AGP1), also known as orosomucoid, is an acute phase protein produced in liver cells and found at high levels...

TLR4 (Toll-like receptor 4) is a mammalain homologue of the Drosophila toll protein. The human TLR4 is a type-1 transmembrane protein containing 799 amino acid residues. The extracellular domain has...

Acetyl-Coenzyme A acetyltransferase 2 (ACAT2) is an enzyme involved in lipid metabolism. Patients with ACAT2 deficiency have shown severe mental retardation and hypotonus. The ACAT2 gene shows...

E5035 | Alpha-2-macroglobulin (Human) ELISA Kit DataSheetAlpha-2-macroglobulin is a large plasma protein mainly produced by the liver. It inhibits a variety of proteinases and binds several types of...

K2041 | Alpha-Mannosidase Activity Assay Kit (Fluorometric) DataSheetAlpha-Mannosidase (α-Man; EC 3.2.1.24) is a glycoside hydrolase involved in the cleavage of the alpha-mannose. α-Man can be...

Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by...

E4940 | Amantadine ELISA Kit DataSheetAmantadine is an antiviral medication that is used to treat dyskinesia, a movement disorder caused by Parkinson's disease. Although the mechanism is not clearly...

RGS3 (regulator of G protein signaling 3) is a 519-residue protein that is widely expressed in many tissues and cells. The protein contains an RGS domain near the carboxy terminus that serves as a...

E4975 | AMH (Human) ELISA Kit DataSheetCystine/glutamate transporter (SLC7A11) is a multi-pass transmembrane protein that belongs to the heterodimeric sodium independent anionic amino acid transport...

The MBD family of proteins includes MeCP2, MBD1, MBD2, MBD3 and MBD4. MBD1 (methyl-CpG binding domain protein 1) binds to methylated CpG sites and represses gene transcription. MBD1 is recruited to...

K229 | AMP Colorimetric Assay Kit DataSheetAdenosine Monophosphate (AMP), also known as 5’-adenylic acid, consists of adenine, ribose and phosphate. AMP can be produced during ATP synthesis by the...

Cytochrome c (m.w. 12,500) is an electron transport protein from mitochondria. It is released from mitochondria to cytoplasm during the early stages of apoptosis, prior to caspase activation, DNA...

K1486 | Amyloid Staining Kit DataSheet’s Amyloid Stain Kit (Congo Red) is used for the histological visualization of amyloid in tissue sections. Examination under a polarizing microscope results in...

Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, and S. The aspartyl protease class contains cathepsin D and E...

E4708 | ANA Screen (Antinuclear Antibody) ELISA Kit DataSheetAntinuclear antibodies (ANA) are frequently present in patients with systemic lupus erythematosus (SLE) and, less commonly, in other...

Caspase-9 is one of the most important caspases among the caspase family members. Upon induction of apoptosis, cytochrome c released from mitochondria associates with procaspase-9/Apaf-1. The complex...

E4615 | Androstenedione ELISA Kit DataSheetAndrostenedione is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from...

Both p44 and p42 MAP kinases (Erk1 and Erk2) function in a protein kinase cascade that plays a critical role in the regulation of cell growth and differentiation. Activation of MAP kinases occurs...

E5037 | Angiopoietin-2 (Human) ELISA Kit DataSheetAngiopoietin-2 (ANG2) belongs to the family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. ANG2 promotes cell...

Inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were initially demonstrated at high frequency in HNPCC and were shown to be associated with...

E4983 | Anti-Jo-1 (Human) ELISA Kit DataSheetSodium-dependent glucose cotransporter 2 (SGLT2) is an integral membrane protein that belongs to the SGLT family of glucose transporters. It is expressed...

Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer’s disease, probably functioning...

E4982 | Anti-MCV (Human) ELISA Kit DataSheetVimentin is a type III intermediate filament protein that is expressed in macrophages and mesenchymal cells. Some of the major functions of vimentin...

NDRG1 is a cytoplasmic protein that is involved in stress responses, hormone responses, cell growth, and differentiation. NDRG1 is one of 4 members of the NDRG ?/?-hydrolase family. It is classified...

E4982 | NRF2 (Human) ELISA Kit DataSheet Nuclear factor erythroid 2-related factor 2 (NRF2, NFE2L2) is a basic leucine zipper transcription factor that belongs to the family of cap ‘n’...

E4983 | SGLT2 (Human) ELISA Kit DataSheet Sodium-dependent glucose cotransporter 2 (SGLT2) is an integral membrane protein that belongs to the SGLT family of glucose transporters. It is expressed in...

E4987 | Anti-NMDAR Antibody (Human) ELISA Kit DataSheetN-methyl-D-aspartate (NMDA) receptor is a glutamate-gated cation channel present in the hippocampus and cerebral cortex. NMDAR plays a critical...

The Toll-like receptor (TLR) family in mammalian comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor...

E5050 | APOA1 (Human) ELISA Kit DataSheetApoA1, also known as apolipoprotein A-I is a major protein component of high-density lipoprotein (HDL) in plasma. It has a specific role in lipid metabolism...

HDAC2 is a class I mammalian histone deacetylase containing 488 amino acid residues with an apparent size of ~55 kDa by denaturing SDS-PAGE. HDAC2 has been shown to interact directly with...

E5038 | ApoB100 (Human) ELISA Kit DataSheetApolipoprotein B (Apo B) is a major protein constituent of chylomicrons (Apo B-48), LDL (Apo B-100) and VLDL (Apo B-100). ApoB-100 (Apolipoprotein B100) is...

HDAC3 is a member of the class I mammalian histone deacetylase family, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC3 is composed of 428 amino acid...

E5005 | AQP4 (Human) ELISA Kit DataSheetAquaporin 4 (AQP4) is a water channel protein that belongs to the aquaporin family of the proteins. AQP4 is abundantly expressed on the perivascular astrocyte...

HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C-terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4,...

E4894 | AREG (Human) ELISA Kit DataSheetAmphiregulin (AREG) is a 23 kD bifunctional glycoprotein that belongs to the epidermal growth factor (EGF) family of proteins. It functions as an autocrine...

The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The N-terminal tail of core histones undergoes different...

E4990 | ARNTL (Human) ELISA Kit DataSheetAryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL, BMAL1) is a basic helix-loop-helix transcription factor with 2 PAS domains. It is a...

COCO, also known as DAND5, Dante, and CKTSF1B3, is a member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus?...

K2031 | Arylamine N-acetyltransferase Activity Assay Kit (Fluorometric) DataSheetArylamine N-acetyltransferases (NATs, EC 2.3.1.5) are a group of cytosolic, conjugating enzymes involved in phase II...

HSD17B4 (17-beta-hydroxysteroid dehydrogenase 4) is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. HSD17B4 catalyzes the formation of 3-ketoacyl-CoA...

E4899 | Asprosin (Human) ELISA Kit DataSheetAsprosin is a novel glucogenic adipokine that plays a critical role in glucose homeostasis. The protein is formed as a result of Furin/PACE (paired basic...

E4964 | ASS1 (Human) ELISA Kit DataSheetArgininosuccinate synthase 1 (ASS1) is an ATP-dependent rate-limiting enzyme in the arginine biosynthetic pathway. ASS1, together with arginosuccinate lyase,...

Beclin is a Bcl-2 binding protein. Its structure includes a Bcl-2 binding coiled-coil region, and a leucine-rich nuclear export signal (NES). Beclin protein colocalizes with intracytoplasmic...

E5008 | ATF4 (Human) ELISA Kit DataSheetActivating transcription factor 4 (ATF4) is 351 amino acid basic leucine zipper (bZIP) stress-responsive transcription factor that belongs to the cAMP response...

BIN-1 is a tumor suppressor protein that was identified in a genetic screen for proteins that interact with the MCY oncoprotein. BIN-1 inhibits the oncogenic activity of MYC, possibly thro?gh...

E4944 | Avermectin ELISA Kit DataSheetAvermectin is a 16-membered macrocyclic lactone derivative that is produced as a fermented product by the soil-dwelling actinomycete Streptomyces avermitilis...

E4945 | Azithromycin ELISA Kit DataSheetAzithromycin is a broad-spectrum antimicrobial drug that is used to treat respiratory, enteric, and genitourinary infections. It targets both gram-positive and...

The p21-activated kinase (PAK) family of serine/threonine kinases is engaged in multiple cellular processes, including cytoskeletal recognization, MAPK signaling, apoptotic signaling, control of...

K1457 | Bacterial DNA Purification Kit II DataSheet's Bacterial DNA Purification Kit II provides a rapid and reliable method for isolating high-quality total DNA from a wide variety of bacterial...

E4879 | Beta-2 Microglobulin (Human) ELISA Kit DataSheetBeta-2 microglobulin (B2M) is a low MW protein (11.8 kDa) that is a component of major histocompatibility complex (MHC) Class I molecule. It is...

Extracellular stimuli such as growth factors and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation at Ser63/73 renders c-Jun...

K2068 | Beta-Glucan Assay Kit (Fluorometric) DataSheetBeta-glucan comprises a group of beta-D-glucose polysaccharides naturally present in the cell walls of grains, bacteria, and fungi. It is a...

PLC (Phosphoinositide-specific phospholipase C) plays a significant role in transmembrane signaling. Four members of PLCs have been identified: PLC?, PLCg, PLCd, and PLCe. In response to...

K2045 | Beta-Mannosidase Activity Assay Kit (Fluorometric) DataSheetBeta-mannosidase (β-Man; EC 3.2.1.25) is an enzyme that hydrolyzes terminal, non-reducing beta-D-mannose residues in...

uPAR (Urokinase plasminogen activator receptor) is a 55 kDa glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface...

E4794 | Bilirubin ELISA Kit DataSheetBilirubin, a degradation product of heme catabolism, is a non-polar molecule. There are two forms of bilirubin: water-soluble (conjugated or direct) and...

BRD8 interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. BRD8 contains a bromodomain and is thought...

FUS has been identified as a frequent translocation fusion partner of various transcription factors. FUS fusion genes have been shown to be associated with multiple tumor types which include...

E4876 | BioSim™ anti-Adalimumab II (Human) ELISA Kit DataSheetAdalimumab is a fully human monoclonal antibody that specifically targets tumor necrosis factor-alpha (TNF-α). TNF is a proinflammatory...

The vertebrate nuclear pore complex (NPC) is a macromolecular assembly of protein subcomplexes forming a structure of eightfold radial symmetry. The NPC core consists of globular subunits sandwiched...

The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. When sufficient...

E4874 | BioSim™ anti-Bevacizumab II (Human) ELISA Kit DataSheetBevacizumab is a humanized IgG1 monoclonal antibody that specifically binds to vascular endothelial growth factor A (VEGF-A) and...

Retinoblastoma binding protein 5 (RbBP5) is a subunit of a human Set1-like histone methyltransferase (HMT) complex. The Set-1 like complexes are responsible for mono-, di-, and tri-methylation of...

MTA1 (metastasis-associated protein 1) is a component of the NURD (nucleosome remodeling and histone deacetylation) complex, which is associated with ATP-dependent chromatin-remodeling and histone...

PPAR (Peroxisome proliferator-activated receptor) is a member of the nuclear hormone receptor superfamily and functions as a transcriptional activator. PPARg is preferentially expressed in adipocyte...

CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently...

E4926 | BioSim™ anti-Durvalumab (Human) ELISA Kit DataSheetDurvalumab is a human IgG1 monoclonal antibody that binds to and inhibits programmed cell death ligand 1 (PD-L1). PD-L1 is an important...

Developmental pluripotency associated 4 (DPPA4) is a nuclear SAP-domain protein whose expression is restricted to pluripotent cells, undifferentiated embryonal carcinomas and germ cell tumors. DPPA4...

Low density lipoprotein receptors (LDLR) are cell surface glycoproteins that regulate LDL cholesterol by scavenging LDL from the blood. LDLR is characterized by a cluster of cysteine-rich class A...

Diacylglycerol acyltransferase is also known as DGAT1 is a microsomal enzyme. It is involved in the synthesis of fatty acids into triglycerides. DGAT utilizes diacylglycerol (DAG) and fatty acyl CoA...

Actin is expressed in all eukaryotic cells and is the major component of the cytoskeleton. At least six types of actin are present in mammalian tissues and fall into three classes. Alpha actin...

E4921 | BioSim™ anti-PD-L1 (Human) ELISA Kit DataSheetAnti-PD-L1 is an Fc-engineered, humanized IgG1 monoclonal antibody that targets programmed cell death ligand 1 (PD-L1). PD-L1 is an important...

E4922 | BioSim™ anti-PD-L1 Mab (Human) ELISA Kit DataSheetAnti-PD-L1 is an Fc-engineered, humanized IgG1 monoclonal antibody that targets programmed cell death ligand 1 (PD-L1). PD-L1 is an important...

Xenopus Dickkopf (Dkk)-1 was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of Dkk have been identified in mammals. Each Dkk molecule...

The Firefly luciferase is a genetically modified variant derived from the Luciferase of Diaphanes pectinealis endemic to Yunnan province, China. It has been modified to provide enhanced stability...

Stearoyl-CoA desaturase (SCD) is a regulatory enzyme involved in the synthesis of oleate and palmitoleate. Oleate and palmitoleate are the main components of membrane phospholipid, triglycerides and...

Xenopus Dickkopf (Dkk) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of Dkk have been identified in mammals. Each Dkk molecule...

Lysosomal-associated membrane protein 2 (LAMP2) also known as CD107B (Cluster of Differentiation 107B) is a membrane glycoprotein. LAMP2 plays an important role in the normal function of lysosome...