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RG-7112 is a Nutlin imidazoline compound that acts as a potent MDM2 inhibitor as well as displays antineoplastic activity. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to...

RG7388 is highly a potent and selective inhibitor of p53-MDM2 interaction. RG7388 blocks p53−MDM2 binding and effectively activates the p53 pathway, leading to cell cycle arrest and/or apoptosis in...

RG7834 is a highly selective and orally bioavailable HBV (Hepatitis B Virus) inhibitor, that potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC₅₀s of 2.8, 2.6, and 3.2 nM,...

RGB-286638 is a potent and selective cyclin-dependent kinase (CDK) inhibitor with IC₅₀ values of 1, 2, 3 and 44 nM for CDK9, CDK1, CDK2, and CDK4, respectively. Less potent against cyclin H-CDK7 and...

RGFP966 is a potent and selective histone deacetylase 3 (HDAC3) inhibitor (IC₅₀ = 80 nM). It does not inhibit other HDACs at concentrations up to 15 µM.RGFP966 is a potent and selective histone...

A natural analog of resveratrol (Cat. No. 1758-100, 500) with antioxidant and anti-cancer activity. Rhapontigenin was found to scavenge intracellular reactive oxygen species (ROS), the...

Rhein is an anthraquinone derivative that displays diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities. Also acts as a Fat mass and obesity-associated...

3789 | Rho Kinase Alpha Antibody DataSheet

A1161 | RhoGDI Antibody DataSheet

RI-1 is a potent and selective inhibitor of RAD51 (IC₅₀ = 5-30 μM). It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the...

Ribavirin is a nucleoside analog that inhibits the replication of both DNA and RNA viruses, including influenza type A and type B. Ribavirin, as ribavirin 5’-phosphate, affects virus-infected cells...

Ribociclib is a potent cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. LEE011 has been shown to reduce...

3957 | Rictor Antibody DataSheet

3957BP | Rictor Blocking Peptide DataSheetAntibody Target: Rictor Accession #: NP_084444Gene ID: 78757Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase, which results in cell death. Active...

Rigor Pcr Mix | M1132

Rigor Pcr Mix-Dye | M1133

Rigosertib is a potent, specific PLK1 (Polo -Like Kinase 1) inhibitor (IC₅₀ = 9 nM). Rigosertib strongly inhibits the proliferation of cancer cell lines, with observed IC₅₀ values in the nanomolar...

Rilpivirine hydrochloride is a diarylpyrimidine derivative that acts as a reverse transcriptase inhibitor with antiviral activity against HIV-1. Rilpivirine is associated with a low rate of transient...

Riluzole is a benzothiazole derivative which inhibits glutamatergic neurotransmission and blocks voltage-dependent sodium channels (ED₅₀ = 2.3 μM). It reduces the uptake of GABA from neuronal synapse...

Rimegepant is an oral antagonist of the calcitonin gene-related peptide (CGRP) receptor (Ki = 0.027 nM). It inhibits cAMP production stimulated by α-CGRP in SK-N-MC human neuroblastoma cells (IC50 =...

3279 | RIP Antibody DataSheet

3279BP | RIP Blocking Peptide DataSheetAntibody Target: RIP Accession #: Q13546Gene ID: 8737Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

3293 | RIP3 Antibody DataSheet

3293BP | RIP3 Blocking Peptide DataSheetAntibody Target: RIP3Accession #: NP_001157580Gene ID: 56532Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

A ready-to-use buffer useful for lysing cells and tissues for radioimmunoprecipitation assay. RIPA buffer also results in low background in immunoprecipitation/pull down assays. The buffer (1X)...

RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with an IC₅₀ of 13 nM. It protects HT-29 cells against TNFα-induced...

Ripasudil (K-115) is a potent inhibitor of Rho kinase (ROCK), with IC₅₀ values of 19 and 51 nM for ROCK-2 and ROCK-1, respectively. Ripasudil (10 μM) induces cytoskeletal changes, including...

RIPK2 (RIP2; RICK) is a death domain-containing protein kinase. Inohara identified cDNAs encoding a predicted 540-amino acid protein RICK, which contains an N-terminal serine/threonine kinase...

Ripretinib is an inhibitor of receptor tyrosine kinase (KIT) and platelet derived growth factor receptor A (PDGFRA). In vitro kinase inhibition studies show that ripretinib inhibits wild-type KIT and...

Risedronate sodium | B3365Description: Risedronate (risedronic acid), is an orally administered pyridinyl bisphosphonate that inhibits osteoclast-mediated resorption of bone and modulates bone...

RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 and induces its accumulation in tumor cells. RITA prevents p53-HDM2 interaction in vitro and in vivo and affects p53...

Ritonavir is an orally bioavailable HIV-1 and HIV-2 protease inhibitor (EC₅₀ values are 0.022-0.13 and 0.16 μM, respectively). Through CYP3A4 inhibition, low doses of ritonavir can reduce the...

Rivaroxaban (BAY 59-7939), is a potent, reversible, small-molecule inhibitor of factor Xa and an antithrombotic agent.Rivaroxaban (BAY 59-7939), is a potent, reversible, small-molecule inhibitor of...

Rivastigmine is a cholinesterase (ChE) inhibitor that inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) with IC₅₀ values of 0.037 μM and 4.15 μM respectively. It is used for the...

Riviciclib hydrochloride is a potent cyclin dependent kinase (CDK) inhibitor (IC₅₀ values of 79 nM, 63 nM and 20 nM for CDK1, CDK4 and CDK9, respectively). Displays potential antineoplastic activity...

RK-33 | B1273

RKI-1313 weak inhibitor for ROCK2-dependent signaling and has less effect on phosphorylation levels of ROCK substrates. RKI-1313 serves as a negative control for RKI-1447 (Cat. No. 2472) which is a...

A highly potent inhibitor of Rho-associated kinases ROCK1 and ROCK2 (IC₅₀ values: 14.5 nM for ROCK1 and 6.2 nM for ROCK2). RKI-1447 suppresses ROCK-dependent signaling, cell morphology,...

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2 (IC50 = 0.583 nM). RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but...

RN 1 dihydrochloride is a potent, cell-permeable, lysine specific demethylase 1 (LSD1) inhibitor (IC₅₀ = 70 nM). Displays selectivity for LSD1 over MAO-A and MAO-B (IC₅₀ values are 0.51 and 2.79 μM...

RN486 is a potent Bruton's tyrosine kinase (Btk) inhibitor (IC₅₀ = 4 nM). When tested with human Ramos B cells or whole blood, RN486 treatment reduces the expression of CD69/B cells proliferation and...

’s RNAkeep™ Solution is a reagent that offers reliable protection and greater stability for cellular RNA at ambient and low temperatures. It is suitable for preserving RNA in cells, fresh clinical or...

RNase A is pancreatic bovine endoribonuclease that cleaves single stranded RNA by hydrolysis at cytosine and uracil residues.M1227 | RNase A DataSheetSort Name: RNase ALabel Name: RNase ATaglines:...

RNase A is an endoribonuclease that specifically cleaves the single strand RNA at the phosphodiester bond between the 5’-ribose of a nucleotide and the 3’ OH phosphate group of an adjacent pyrimidine...

RNase H (Ribonuclease H), E. coli is an endoribonuclease that specifically hydrolyzes the phosphodiester bonds of RNA strands in RNA-DNA hybrids. This enzyme cleaves the 3’-O-P-bond of RNA and...

RNase III, E.coli is an endoribonuclease that specifically digests dsRNA into dsRNA fragments of 12-15 base pairs that have two or three nucleotide 3´-overhangs with 5' phosphate and 3' hydroxyl...

RNase R is an E. coli exoribonuclease which exhibits 3’-to-5’ exonuclease activity, efficiently digesting nearly all linear RNA species. M1228 | RNase R DataSheetSort Name: RNase RLabel Name: RNase...

RNaseOFF Ribonuclease Inhibitor specifically inhibits common ribonucleases (RNases), including RNase A, B and C, with high affinity and is a useful additive in PCR or RT-PCR as it does not inhibit...

’s RNaseRIP™ Solution is a decontamination solution that sends RNases to their grave. It destroys RNase on contact, irreversibly by denaturing it. RNaseRIP™ Solution is supplied in an HDPE plastic...

Ro 08-2750 is an antagonist of nerve growth factor (NGF). It binds to the NGF dimer (Kd ~ 1 μM) and probably induces a change in its conformation such that NGF cannot bind to neurotrophin receptor...

Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also...

Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC₅₀ = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits...

Ro 48-8071 is a selective 2,3-Oxidosqualene:lanosterol cyclase (OSC) inhibitor (IC₅₀ = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Ro 48-8071 exerts strong anti-angiogenic activity by...

Cell-permeable. A high-affinity small molecule inhibitor of KMO (kynurenine 3-monoxygenase or kynurenine 3-hydroxylase)(Ki = 4.8 nM, IC₅₀ = 37 nM).Ro 61-8048 is a high-affinity small molecule...

Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to...

RO-5006036 (DGAT1-IN-3) also known as DGAT1-IN-3, is a potent, selective and orally bioavailable inhibitor of DGAT-1 (Diacylglycerol O-acyltransferase 1).RO-5006036 (DGAT1-IN-3) also known as...

RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1 (IC₅₀ = 3 nM).RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1 (IC₅₀ = 3 nM).B1175 | Ro3280...

RO4929097 is a small molecule γ-secretase inhibitor (IC₅₀ = 4 nM). It binds to γ-secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits...

Ro5126766 (CH5126766) is a potent and selective dual RAF/MEK inhibitor. For SK-MEL-28, SK-MEL-2, MIAPaCa-2, and SW480 cell lines, the IC50 is determined by WST-8 assay is 65, 28, 40, and 46 nM,...

RO8994 is a highly potent and selective spiroindolinone small-molecule MDM2 inhibitor, with IC₅₀ of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).RO8994 is a highly potent and...

Robenacoxib is a non-steroidal anti-inflammatory drug (NSAID), that acts as a potent and selective inhibitor of cyclooxygenase-2 (COX-2). Robenacoxib is a non-steroidal anti-inflammatory drug...

Robenidine hydrochloride is an antibiotic used as an effective anticoccidial. It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature...

Roblitinib is a reversible-covalent inhibitor of fibroblast growth factor receptor 4 (FGFR4) tyrosine kinase. It shows 1000-fold selectivity for FGFR4 over FGFR1/2/3 and other kinases, with an IC₅₀...

3625 | ROBO4 Antibody DataSheet

3625BP | ROBO4 Blocking Peptide DataSheetAntibody Target: ROBO4Accession #: Q80W87Gene ID: 300518Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling, that blocks hedgehog signaling through specific binding and blockade of Shh signaling factor. It is the first-characterized...

Robust Ready DNA Polymerase | M1147

2X PCR MasterMixM1130 | Robust Ready™ PCR Mix DataSheetSort Name: Robust Ready™ PCR MixLabel Name: Robust Ready™ PCR MixTaglines: 2X PCR MasterMixProduct Highlights: 2X PCR MasterMixPackaging: 25.0...

2X PCR MasterMix with dyeM1131 | Robust Ready™ PCR Mix-Dye DataSheetSort Name: Robust Ready™ PCR Mix-DyeLabel Name: Robust Ready™ PCR Mix-DyeTaglines: 2X PCR MasterMix with dyeProduct Highlights: 2X...

An immunosuppressant and a potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits...

A cell-permeable, ATP-competitive inhibitor of Rho kinase (ROCK) activity in vitro (IC₅₀ = 25 µM). Inhibits blebbing o trypsinized Swiss3T3 and M2 cells.Rockout is a cell-permeable, ATP-competitive...

ROCK Inhibitor-II inhibits the Rho kinase ROCK-II with an IC₅₀

3545 | ROCK1 Antibody (Clone 12M03) DataSheet

Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent cyclooxygenase-2 (COX-2) inhibitor. It displays 1,000-fold selectivity for COX-2 over that of COX-1 (IC₅₀s = 26 nM...

Roflumilast is a selective phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 0.8 nM). Displays anti-inflammatory properties.Roflumilast is a selective phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 0.8 nM)...

Rogaratinib (BAY-1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor.Rogaratinib (BAY-1163877) is a potent and selective fibroblast growth factor receptor (FGFR)...

6701 | ROR2 Antibody (CT) DataSheet

6700 | ROR2 Antibody (NT) DataSheet

Roridin E is a macrocyclic trichothecanoid isolated from several fungi. It displays activity against arenavirus JUNIN (JUNV), the etiological agent of Argentine hemorrhagic fever.Roridin E is a...

Cell-permeable. A potent inhibitor of p34cdc2 (IC₅₀ = 0.2 µM). Also inhibits p33cdk2 and p33cdk5.Roscovitine is a potent inhibitor of p34cdc2 (IC₅₀ = 0.2 µM). Also inhibits p33cdk2 and p33cdk5.1950 |...

Cell-permeable. Rose Bengal is a polyhalogenated fluorescein derivative that acts as a potent inhibitor (K(i) = 19 nM) of glutamate uptake into isolated synaptic vesicles. This vesicular Glu uptake...

Belongs to the thiazolidinedione class of anti-diabetic drugs. A selective ligand of PPARγ and has no PPARα-binding actionRosiglitazone belongs to the thiazolidinedione class of anti-diabetic drugs...

A natural polyphenoic antioxidant carboxylic acid found in many Lamiaceae herbs. Displays anti-inflammatory, cytostatic and antiviral activities. Inhibits several complement-dependent inflammatory...

Rosuvastatin belongs to a class of compounds called statins that is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It competitively inhibits...

A broad spectrum insecticide that is cell-permeable and brain-permeable. Acts as a mitochondrial electron transport chain inhibitor (IC₅₀ = 1.7 - 2.2 μM at complex I). Inhibits NADH oxidation by...

Originally reported as an inhibitor of Protein Kinase C isoforms with selectivity for PKCδ. However, more recent studies have shown Rottlerin did not block PKCδ activity but did block other kinase...

Roxithromycin is a semi-synthetic, macrolide antibiotic, derived from erythromycin A. It acts as a bacteriostatic drug at low concentrations and a bactericidal drug at high concentrations. It binds...

RQ-00203078 is a potent, selective TRPM8 antagonist (IC₅₀ values are 5.3 and 8.3 nM for rat and human channels respectively). Displays >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1...

RS-1 (RAD51-stimulatory compound 1) is a high affinity stimulator of the human homologous recombination (HR) protein RAD51. RS-1 stimulates binding of hRAD51 to single stranded DNA (ssDNA) and...

RS-504393 is a selective CCR2 chemokine receptor antagonist (IC₅₀ values are 98 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis...

RSC-133 is an epigenetic modulator that effectively improves reprogramming of human somatic cells to pluripotent stem cells. Apparently, RSC-133 facilitates the reprograming by dual inhibition of...

The RSK (ribosomal S6 kinase) family comprises growth factor-regulated serine/threonine kinases, known also as p90(rsk). RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates...

3546 | RSK2 Antibody DataSheet

RSK2 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to...

RSK3 is a member of the RSK (ribosomal S6 kinase) family that encodes a 733-amino-acid protein with a unique N-terminal region containing a putative nuclear localization signal (1). RSK3 mRNA is...

RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor and an inducer of ferroptosis. RSL3 increases lipid peroxidase levels in vitro and inhibits tumor formation and progression in vivo.RSL3 is a...

RSV-604 is a novel inhibitor of respiratory syncytial virus (RSV) replication (EC₅₀ = 0.86 uM). Potentially useful for the treatment of respiratory syncytial virus infections.RSV-604 is a novel...

RTA 408 is a synthetic oleanane triterpenoid that activates Nrf2. RTA 408 activates Nrf2 and suppresses nitric oxide and pro-inflammatory cytokine levels in interferon-γ-stimulated RAW 264.7...

RTA-402 is a synthetic triterpenoid compound with anti-inflammatory, antitumor and cytoprotective properties. RTA-402 is a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator. CDDO-Me...