26

3459BP | SGK Blocking Peptide DataSheetAntibody Target: SGK Accession #: O00141Gene ID: 6446Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

SGK1 is a member of the serum- and glucocorticoid-induced protein kinase that is activated in vitro by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and in vivo in response to signals that...

SGK2 is a member of the serum- and glucocorticoid-induced kinases (SGK) which are serine-threonine kinases and belong to the "AGC" kinase subfamily, which includes protein kinases A, G, and C, and...

3711 | SGLT-1 Antibody DataSheet

3711BP | SGLT-1 Blocking Peptide DataSheetAntibody Target: SGLT-1 Accession #: P13866Gene ID: 6523Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) SGLT-1 peptide in...

3690 | SGLT-2 Antibody DataSheet

3690BP | SGLT-2 Blocking Peptide DataSheetAntibody Target: SGLT-2 Accession #: Q923I7Gene ID: 246787Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

SGX-523 is a selective inhibitor of Met with IC50 of 4 nM.SGX-523 is a selective inhibitor of Met with IC50 of 4 nM.B1336 | SGX-523 DataSheetAlternate Name/Synonyms:...

SH-4-54 is a most potent, small molecule, non-phosphorylated STAT3 inhibitor, strongly binds to STAT3 protein (KD = 300 nM), is selective for STAT3 over STAT1.SH-4-54 is a most potent, small...

A cell-permeable inhibitor of Akt activation without affecting the activation of the upstream kinase PDK1 or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of...

SH-6 | 1819

5317 | SHANK3 Antibody (Center) DataSheet

A1017 | SHH Polyclonal Antibody DataSheet

Shikonin is a naturally occurring naphthoquinone derivative that displays anti-inflammatory and antitumor properties. Displays anti-angiogenic properties by inhibition of proliferation and migration...

SHP-2, also known as, tyrosine-protein phospatase non-receptor type 11(PTPN11), is a member of the protein tyrosine phosphatase (PTP) family containing two Src homology 2 domains. This protein...

SHP099 is a potent, and selective, SHP2 inhibitor (IC50 = 0.07 μM) and p-ERK modulation in cells (IC₅₀ = 0.250 μM). SHP099 displays dose-dependent pathway inhibition and antitumor activity in...

Shrimp Alkaline Phosphatase (SAP) is a high specific activity, heat-labile alkaline phosphatase purified from a recombinant source and originally isolated from Pandalus borealis (arctic shrimp).9216...

Cell-permeable. A sulfonylhydrazone (Shz) small molecule that acts as an enhancer of myocardial regenerative repair by stem cells. Potently induces Nkx2.5 and a subset of other cardiac markers,...

3238 | SIAH3 Antibody DataSheet

3238BP | SIAH3 Blocking Peptide DataSheetAntibody Target: SIAH3Accession #: NP_001178047.1Gene ID: 692004Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

K566 | Sialic Acid NANA Colorimetric/Fluorometric Assay Kit DataSheet

K4223 | Sialic Acid SA Elisa Kit DataSheet

IL-4 can signal through type I and type II receptor complexes, which share a common chain (c). The type I receptor contains in addition to the chain an IL-4R subunit, whereas the type II receptor...

Sildenafil citrate is a potent, orally active phosphodiesterase 5 (PDE5) inhibitor (IC₅₀ = 4 nM). Inhibition of PDE5 enhances the relaxation of smooth muscle in a range of vascular tissues by...

Silvestrol is a natural product isolated from the fruits and twigs of Aglaia foveolata. Acts as a eukaryotic translation initiation factor 4A (eIF4A) inhibitor. Also displays broad-spectrum antiviral...

Simeprevir is a potent inhibitor of HCV NS3/4A protease with Ki value of 0.36 nM.Simeprevir is a potent inhibitor of HCV NS3/4A protease with Ki value of 0.36 nM.B1173 | Simeprevir DataSheetAlternate...

A synthetic analog of Lovastatin (Cat. No. 1692-50, 250). Cholesterol lowering drug and a competitive inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase. Inhibits the biosynthesis...

SIN-1 is a metabolite of molsidomine that spontaneously releases nitric oxide (NO) and superoxide anion which react to form peroxynitrite under physiological conditions. Acts as a potent...

3971 | Sin1 Antibody DataSheet

3971BP | Sin1 Blocking Peptide DataSheetAntibody Target: Sin1Accession #: NP_796319Gene ID: 227743Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Sinefungin is a natural nucleoside and a structural analog of S-adenosylmethionine (SAM). It inhibits SAM-dependent nucleic acid methyltransferases and exhibits antifungal, antiviral, and...

Single Stranded DNA Binding Protein (SSB) is a homo-tetrameric protein, which binds onto single stranded DNA (ssDNA) to coordinate replication, repair, and recombination. It possesses a N-terminal...

Sinomenine is a natural plant alkaloid that displays anti-inflammatory properties. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing...

Siponimod is an orally bioavailable agonist of the sphingosine-1-phosphate (S1P) receptor that is selective for S1P1 and S1P5 with EC₅₀ values of 0.39 and 0.98 nM respectively, in a GTPγS-binding...

Siramesine is an agonist for sigma-2 (σ2) receptor. It is selective for σ2 over σ1 with IC₅₀ values of 0.12 nM and 17 nM respectively. It shows potent anxiolytic-like effects in rodents. The minimal...

pGB expression vectors contain the human U6 RNA polymerase III promoter, which directs constitutive, high-level expression of short RNA transcripts in many cells. Each vector also contains the...

E4554 | SIRPA / CD172a Human Elisa Kit DataSheet

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the...

6137 | SIRT1 Antibody DataSheet

A potent SIRT1 inhibitor (IC₅₀ = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations...

K325 | SIRT1 Inhibitor/Activator Screening Kit Fluorometric DataSheet

6138 | SIRT2 Antibody DataSheet

K322 | SIRT2 Inhibitor Screening Assay Kit Fluorometric DataSheet

Brain- permeable. A potent and selective sirtuin 2 deacetylase (SIRT2) inhibitor. Reduces neuronal cholesterol by inhibiting SIRT2 activity.SIRT2 inhibitor is a brain-permeable, potent and selective...

A potent inhibitor of sirtuin 2 (SIRT2) (IC₅₀ = 3.5 µM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion...

Cell-permeable. A Sirtuin 2 (SIRT2) inhibitor (IC50 = 35 µM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated...

3223 | SIRT3 Antibody DataSheet

3223BP | SIRT3 Blocking Peptide DataSheetAntibody Target: SIRT3Accession #: Q9NTG7Gene ID: 23410Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

There are seven human sirtuins, also known as class III HDACs, which have been designated SIRT1 to SIRT7. Each is involved in various post-translational modifications by utilizing NAD dependent...

3224 | SIRT4 Antibody DataSheet

3224BP | SIRT4 Blocking Peptide DataSheetAntibody Target: SIRT4Accession #: B2RZ30Gene ID: 1310413. Sirt4. Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the...

3225 | SIRT5 antibody DataSheet

3225BP | SIRT5 Blocking Peptide DataSheetAntibody Target: SIRT5Accession #: Q9NXA8 Gene ID: 23408Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

6692 | SIRT6 Antibody DataSheet

K323 | SIRT6 Inhibitor Screening Kit Fluorometric DataSheet

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the...

3099 | SIRT7 antibody DataSheet

3099BP | SIRT7 Blocking Peptide DataSheetAntibody Target: SIRT7Accession #: B2RZ55Gene ID: 303745Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

SirtAct is a potent Sirtuin 1 (SIRT1) activator. It increases fluorescence by 233% in a SIRT1 activity assay. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in...

Cell-permeable. A selective sirtuin deacetylase inhibitor with IC50 values of 38, 68 and 131 μM for SIRT2, Sir2p and SIRT1 respectively. Sirtinol has no effect on HDAC1 activity. Sirtinol inhibits...

K4923 | Sirtuin 1 human intracellular Elisa Kit DataSheet

K4924 | Sirtuin 2 human intracellular Elisa Kit DataSheet

Human sirtuins function as intracellular regulatory proteins. Sirtuin 2 is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include...

Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of...

K324 | Sirtuin Activity Assay Kit Fluorometric DataSheet

An anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon...

Sitravatinib (MGCD516; MG516) is a potent receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2,...

Sivelestat (ONO-5046) is a potent neutrophil elastase inhibitor. It acts as a substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC₅₀ = 19-49 nM in rat, rabbit, hamster,...

SJA710-6 is a Hepatic Differentiation Inducer that selectively induces the differentiation of rat Mesenchymal stem cells (rMSCs) toward hepatocyte-like cells in vitro.SJA710-6 is a Hepatic...

Skepinone-L is a potent, ATP-competitive inhibitor of p38 MAPK isoform p38α (IC₅₀ = 5 nM) and p38β (97% inhibition at 1 µM). It has little effect on a range of other kinases, including p38γ and p38δ...

SKF-38393 hydrochloride acts as a selective D1/D5 (dopamine D1/D5) receptor partial agonist. It has stimulant and anorectic effects. SKF 38393 improves temporal order memory performance in maternally...

SKF-86002 is a p38 MAP kinase inhibitor (IC₅₀ = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC₅₀ = 1 μM). Also acts as an inhibitor of both cyclooxygenase...

SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibits angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and...

Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes...

SKQ1 bromide is a cell-permeable mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS). SKQ1 prevents neuronal loss and synaptic...

A non-peptidic anti-diabetic agent and a receptor-selective glucagon antagonist. Also acts as an antioxidant, free radical and singlet oxygen species scavenger.Skyrin, Talaromyces sp. Is a...

SL0101 is a potent and selective inhibitor of ribosomal S6 kinase (RSK) (IC₅₀ = 89 nM for RSK2). Does not have any effect on upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7...

SL-327 is a selective inhibitor of MEK1 and MEK2 with IC50 value of 0.18 and 0.22 μM, respectively.SL-327 is a selective inhibitor of MEK1 and MEK2 with IC50 value of 0.18 and 0.22 μM, respectively...

SLAM family member 6, also known as SLAMF6, belongs to the SLAM family of immune cell receptors. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a...

5534 | SLC Antibody DataSheet

3746 | SLK Antibody DataSheet

SM-164 is a potent cell-permeable and bivalent Smac mimetic which binds to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM,...

3298 | Smac/DIABLO Antibody DataSheet

3298BP | Smac/DIABLO Blocking Peptide DataSheetAntibody Target: Smac/DIABLO Accession #: Q9JIQ3Gene ID: 66593Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

3461 | Smad1 Antibody DataSheet

3461BP | Smad1 Blocking Peptide DataSheetAntibody Target: Smad1 Accession #: P97588Gene ID: 25671Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

K4234 | SMAD2 Human Elisa Kit DataSheet

K4200 | SMAD3 Human Elisa Kit DataSheet

A potent and selective inhibitor of Smad3 function. SIS3 selectively inhibits TGF-β1/ALK5-induced Smad3 phosphorylation. Also inhibits the TGF-β1 effect on type I procollagen expression at the...

3464 | Smad4 Antibody DataSheet

3464BP | Smad4 Blocking Peptide DataSheetAntibody Target: Smad4 Accession #: BAB40977Gene ID: 4089Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg(0.5 mg/ml) in phosphate...

3465 | Smad5 Antibody DataSheet

3670 | Smad7 Antibody DataSheet

3670BP | Smad7 Blocking Peptide DataSheetAntibody Target: Smad7 Accession #: BC027307Gene ID: 94044Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

6156 | SMARCA4 Antibody DataSheet

3754 | SMC2 Antibody DataSheet

3876 | SMC4/CAPC Antibody DataSheet

SMER-3 (Small molecule enhancer of rapamycin -3) is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes that results...

Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates...