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SMI-16a is a potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC₅₀ = 150 nM and 20 nM against Pim-1 and Pim-2, respectively).SMI-16a is a potent, cell-permeable, ATP-competitive...

A selective, ATP-competitive inhibitor Pim-1 (IC₅₀ = 21 nM) and Pim-2 (IC₅₀ = 100 nM) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer...

Tudor domains are small protein structural motifs of ~50 amino acids related to the “Royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains...

SAG hydrochloride is the water-soluble analog of SAG (Cat. No.1939). A cell-permeable Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine...

Cell-permeable. A Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine inhibition of Smo. SAG has been reported to act as an activator at low...

A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 3.1 µM). Also...

SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the...

SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia...

A1058 | SMO Antibody (Center) DataSheet

SNAP-37889 is a galanin-3 receptor (GAL3) antagonist. Reduces ethanol self-administration and cue-induced re-instatement in alcohol-preferring (iP) rats with no alterations in locomotor activity or...

SNS-032 is a potent CDK inhibitor. Inhibits cyclin-dependent kinases (cdks) 9, 2 and 7 with IC₅₀ values of 4, 38 and 62 nM respectively. Displays no activity against 190 additional kinases (IC₅₀...

A potent pan-Aurora kinase inhibitor. Inhibits Aurora kinases A, B, and C with IC₅₀ values of 9 nM, 31 nM and 3 nM, respectively. Displays potent anti-tumor activity.SNS-314 is a potent pan-Aurora...

SNX-2112 is a potent heat-shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. SNX-2112 selectively accumulates in tumors compared to normal tissues and binds to the N-terminal...

3861 | SOCS1 Antibody DataSheet

3861BP | SOCS1 Blocking Peptide DataSheetAntibody Target: SOCS1 Accession #: Q9QX78Gene ID: 252971Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3221 | SODD Antibody DataSheet

Inhibitor of histone deacetylase (HDAC). Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.Sodium 4-phenylbutyrate is an inhibitor...

Provided as a stock solution for making various biological buffers and salt solutions2118 | Sodium Acetate (NaAc 3 M pH 5.2) DataSheetSort Name: Sodium Acetate (NaAc 3 M pH 5.2)Label Name:...

K391 | Sodium Assay Kit Colorimetric DataSheet

A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes...

A sterile-filtered solution of 0.9% Sodium chloride in de-ionized water.A sterile-filtered solution of 0.9% Sodium chloride in de-ionized water.9628 | Sodium Chloride (0.9%), Sterile-Filtered...

5 M sodium chloride solution.2101 | Sodium Chloride Solution (NaCl) DataSheetSort Name: Sodium Chloride Solution (NaCl)Label Name: N/ATaglines: 5M NaCl solutionProduct Highlights: AMOUNT: 100 ml (5...

Deoxycholic acid sodium is a water-soluble, anionic detergent useful for extraction of membrane receptors and other plasma membrane proteins and for nuclei isolation.Deoxycholic acid sodium is a...

Sodium dichloroacetate is an inhibitor of pyruvate dehydrogenase kinase (PDK). It shows IC₅₀ values of 183 μM and 80 μM for PDK2 and PDK4 respectively. DCA causes apoptosis in cancer cells and...

Sodium Orthovanadate is a commonly used general inhibitor for protein tyrosine phosphatases (PTPs). It is a competitive inhibitor. The inhibition by Vanadate is completely reversible upon the...

Activated Sodium orthovanadate is a depolymerized vanadate prepared from Sodium orthovanadate (Cat. No. 9470) that displays enhanced ability to inhibit endogenous phosphatases in a competitive manner...

Oxamate is a known glycolysis inhibitor with its target being lactate dehydrogenase (LDH).Oxamate is a known glycolysis inhibitor with its target being lactate dehydrogenase (LDH).2580 | Sodium...

Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid. Acts as a useful detergent for the solubilization of lipids and membrane–bound proteins...

Tauroursodeoxycholic acid (TUDCA) is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid. TUDCA is found in small quantities in human bile but at a higher concentration in the...

K1411 | Soil Genomic DNA Kit DataSheet

Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicinal herb, Solanum nigrum L. (SNL). It has been shown to inhibit growth and induce apoptosis of various...

Solithromycin (CEM-101) is a "fourth-generation" macrolide antibiotic, that has three binding sites and is acid stable. The three binding sites confer activity against bacteria resistant to the older...

K532 | Soluble Collagen Assay Kit Fluorometric DataSheet

K477 | Soluble Epoxide Hydrolase Activity Assay Kit Fluorometric DataSheet

K480 | Soluble Epoxide Hydrolase Inhibitor Screening Kit Fluorometric DataSheet

Recombinant Mouse Sonic Hedgehog is a member of a small group of secreted proteins that are essential for development in both vertebrates and invertebrates. Three mammalian hedgehog genes (sonic,...

Sonic Hedgehog human recombinant H-SHH | 7883

K935 | Sorbitol Dehydrogenase Activity Assay Kit Colorimetric DataSheet

Sotrastaurin (AEB071) is a potent pan-PKC (Protein Kinase C) inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively...

Mucicarmine Solution (Southgate's) is a component of the Mucicarmine Stain Kit (Cat# K1430) and is intended for use in the histological visualization of acid mucopolysacharides in tissue sections...

3822 | Sox-1 Antibody DataSheet

6772 | Sox-2 Antibody (Clone # 57CT23.3.4) DataSheet

3889 | Sox-2 Antibody DataSheet

3889BP | Sox-2 Blocking Peptide DataSheetAntibody Target: Sox-2Accession #: CAA83435Gene ID: 6657Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3822BP | Sox1 Blocking Peptide DataSheetAntibody Target: Sox1 Accession #: P53783Gene ID: 20664Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

K4199 | SOX2 Human Elisa Kit DataSheet

Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain,...

Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain,...

SP-2509 is a reversible inhibitor of Lysine-specific demethylase (LSD1) (IC₅₀ = 13 nM). It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to CoREST, allowing...

3887 | Sp3 Antibody DataSheet

3887BP | Sp3 Blocking Peptide DataSheetAntibody Target: Sp3 Accession #: AAH42945Gene ID: 6670Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

Cell-permeable. A selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC₅₀ = 40-90 nM) with negligible activity at ERK2, p38β and a range of...

SPARC/Osteonectin is a secreted, evolutionarily conserved collagen-binding glycoprotein that is involved in a variety of cellular activities. It is highly expressed in tissues undergoing...

Cell-permeable. A specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and...

KEY FEATURES: • SPDP contains a dithiopyridyl group which is reactive towards cysteines (-SH groups) and an NHS group, which is useful when targeting primary amines (-NH2 groups) • SPDP releases a...

Spectinomycin is an aminocyclitol antibiotic that inhibits protein synthesis and elongation by binding to the bacterial 30S ribosomal subunit and interfering with peptidyl tRNA translocation. It has...

K600 | Sphingomyelin Quantification Colorimetric Assay Kit DataSheet

K599 | Sphingomyelinase Activity Colorimetric Assay Kit DataSheet

K574 | Sphingomyelinase Activity Fluorometric Assay Kit DataSheet

3883BP | Sphingosine Kinase 1 (SPK1) Blocking Peptide DataSheetAntibody Target: Sphingosine Kinase 1 (SPK1)Accession #: CAM17115Gene ID: 20698Appearance: Colorless liquidConcentration: 0.5...

3883 | Sphingosine Kinase 1 (SPK1) Antibody DataSheet

3884BP | Sphingosine Kinase 2 (SPK2) Blocking Peptide DataSheetAntibody Target: Sphingosine Kinase 2 (SPK2) Accession #: AAH79120Gene ID: 308589Appearance: Colorless liquidConcentration: 0.5...

3884 | Sphingosine Kinase 2 (SPK2) Antibody DataSheet

Cell-permeable. SKI-I is a non-lipid pan-sphingosine kinase (SK) inhibitor that inhibits both SK1 and SK2 to suppress the production of pro-mitogenic sphingosine 1-phosphate (S1P) and promote cell...

Cell-permeable. SKI-II is selective a non-lipid sphingosine kinase (SK) inhibitor. It displays non-ATP-competitive inhibition of human recombinant GST-SK 1 with an IC50 value of 0.5 µM, with no...

SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) IC₅₀ = 5.9 nM). It displays selectivity for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31...

6656 | SPHKAP Antibody DataSheet

6656BP | SPHKAP Blocking Peptide DataSheetAntibody Target: SPHKAPAccession #: Q2M3C7Gene ID: 80309Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Potent inhibitor of yeast NAD⁺-dependent histone deacetylase Sir2p (IC₅₀ = 60 µM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either...

Cell-permeable. SQ 22,536 is an adenylyl cyclase inhibitor. (IC₅₀ = 1.4 μM). It inhibits cAMP production induced by prostaglandin E1 in platelet lysates (IC₅₀ = 82 µM) and in intact platelets (IC₅₀ =...

SR-144528 is a cannabinoid (CB) receptor 2 inverse agonist (Ki values ranging from 0.3 to 5.6 nM). Displays >700-fold selectivity for CB2 over CB1 receptors. Blocks the effects of CP-55,940 on...

SR-4370 is a potent and selective inhibitor of histone deacetylase 3 (HDAC3; IC50 = 6 nM). It displays selectivity for HDAC3 over HDAC1, -2, -6, and -8 (IC50s = 0.13, 0.58, 3.7, and 2.3 µM,...

SR-717 is a non-nucleotide STING (stimulator of interferon (IFN) genes) agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a...

Cell-permeable. A high affinity synthetic ligand specific to both retinoic acid-related orphan receptors ɑ (RORɑ) and γt (RORγt). SR1001 inhibits interleukin-17 (TH17) cell differentiation and...

SR1664 blocks phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) by cyclin-dependent kinase 5 with an IC₅₀ value of 80 nM (Ki = 28.7 nM) without displaying agonist activity at...

SR7826 is a potent and selective LIMK inhibitor with IC₅₀ values 43, 5536 and 6565 nM for LIMK1, ROCK1 and ROCK2 respectively. It has shown to inhibit cofilin phosphorylation in A7r5 cells. In vitro...

SR9009 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERB α (IC50=670 nM) and REV-ERBβ (IC50 = 800 nM). SR9009 decreases the circadian locomotor activity...

SR9243 is a potent , cell-permeable and selective LXR inverse agonist. SR9243 kills cancer cells by inhibiting lipid production and the Warburg effect. It induces cell death in multiple types of...

3780 | SRA Antibody DataSheet

5557 | sRANK Ligand Polyclonal Antibody DataSheet

Human RANK (receptor activator of NF-kB) is a member of the TNFR family, identified as a dentritic cell membrane protein. Human soluble RANK Ligand is a soluble 20.0 kDa polypeptide, comprising the...

Murine RANK (receptor activator of NF-kB) is a newly discovered member of the TNFR family, identified as a dendritic cell membrane protein. The recombinant murine sRANK Ligand is a soluble 19.4 kDa...

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally...

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally...

Src family belongs to non-receptor tyrosine kinases. Src was originally identified as a transforming protein of the Rous sarcoma virus (RSV) that had enzymatic ability to phosphorylate tyrosine in...

3773 | SRC3 Antibody DataSheet

3961 | SREBP1 Antibody DataSheet

3961BP | SREBP1 Blocking Peptide DataSheetAntibody Target: SREBP1 Accession #: P56720. Gene ID: 78968Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

An ATP-competitive, serine/arginine-rich protein kinase (SRPK)-specific inhibitor (Ki = 0.89 µM for SRPK1). SRPIN 340 does not inhibit other classes of Serine-Arginine-Rich Protein Kinases (SRPKs)...

SRT-3025 is a potent and selective Sirt1 activator. It inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival. SRT-3025 inhibits...

SRT1720 is a selective SIRT1 activator (EC₅₀ = 0.16 μM). It displays >230-fold less potency against SIRT2 and SIRT3.SRT1720 is a selective SIRT1 activator (EC₅₀ = 0.16 μM). It displays >230-fold less...

offers miRNA mimics, which are RNA oligonucleotides designed to mimic endogenous mature microRNAs (miRNAs) for use in miRNA function research. Each microRNA mimics includes one strand that is...

offers miRNA mimics, which are RNA oligonucleotides designed to mimic endogenous mature microRNAs (miRNAs) for use in miRNA function research. Each microRNA mimics includes one strand that is...

SSAA09E1 is a novel inhibitor of SARS-CoV (Severe acute respiratory syndrome-Coronavirus) replication, acting by blocking cathepsin L, a host protease required for processing of SARS-S during viral...

SSAA09E2 is a novel inhibitor of SARS-CoV (Severe acute respiratory syndrome-Coronavirus) replication, acting by blocking early interactions of SARS-S with the receptor for SARS-CoV, Angiotensin...

SSE-15206 is a pyrazolinethioamide derivative that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents...

3063 | SSEA-1 Antibody (Clone MC-480) DataSheet

3065 | SSEA-3 Antibody DataSheet

3074 | SSEA-4 Antibody (Clone MC-813-70) DataSheet

SSR-240612 is a potent and selective, non-peptide antagonist of the bradykinin B1 receptor (Kis = 0.48-0.73 and 358-481 nM for B1 and B2 receptors, respectively). It inhibits the contraction of...