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3222 | TACE Antibody DataSheet

TACE human Elisa Kit | K4754

K366 | TACE Inhibitor Screening Assay Kit Fluorometric DataSheet

TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and...

TAE (Tris-Acetate-EDTA) buffer (50X) is used for electrophoresis of nucleic acids in agarose and polyacrylamide gels. This buffer can be used for both genomic and large supercoiled DNA, as well as...

TAE-226 is a potent ATP-competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE-226 can block FAK and IGF-IR signaling pathways. TAE-226 inhibits the phosphorylation of FAK as...

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such...

6845 | TAF1 polyclonal antibody DataSheet

TAFA proteins are a newly discovered family of proteins, which are distantly related to MIP-1alpha, a member of the CC-chemokine family. TAFA mRNAs are highly expressed in specific brain regions. The...

Tafamidis is a potent kinetic stabilizer of transthyretin (TTR). Tafamidis binds selectively and with negative cooperativity (Kd values ∼2 nM and ∼200 nM) to the two normally unoccupied...

Cell-permeable. A potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase (IC₅₀ = 6 nM). Displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. TAK 165...

TAK-063 is a highly potent, cell-permeable PDE10A inhibitor (IC₅₀ = 0.30 nM) with excellent selectivity (>15000-fold selective over other PDEs).TAK-063 is a highly potent, cell-permeable PDE10A...

A selective pan-RAF inhibitor with IC₅₀ Values: 2.4 nM (BRAF V600E); 1.4 nM (C-RAF); 160 nM (VEGFR). TAK-632 displays significant cellular activity against mutated BRAF or mutated NRAS cancer cell...

TAK-700 is a potent and highly selective human 17,20-lyase inhibitor (IC₅₀ = 38 nM). Displays >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Displays antiandogen activity...

TAK-715 is a selective inhibitor of p38 MAPK with IC50 value of 7.1 nM.TAK-715 is a selective inhibitor of p38 MAPK with IC50 value of 7.1 nM.B1701 | TAK-715 DataSheetAlternate Name/Synonyms:...

A potent, selective, non-ATP competitive, allosteric MEK inhibitor. TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins...

TAK-901 is a potent inhibitor of Aurora kinases A and B with IC₅₀ value of 21 nM and 15 nM, respectively. Displays antineoplastic activity.TAK-901 is a potent inhibitor of Aurora kinases A and B with...

Takinib is a potent and selective TAK1 inhibitor (IC₅₀ = 9.5 nM). Sensitizes cells to TNF-α-induced cell death, with potential implications for cancer and autoimmune diseases.Takinib is a potent and...

Talabostat is a nonselective inhibitor of post-proline cleaving serine proteases. The inhibition of the highly related cytosolic serine proteases Dpp8 and Dpp9 (Dpp8/9) by Val-boroPro was recently...

A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1...

A potent synthetic anti-estrogenic agent. A reversible inhibitor of protein kinase C (IC₅₀ = 10 mM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by...

Cell-permeable. A potent inhibitor of Fms-like tyrosine kinase 3 (FLT3) kinase, PDGFRβ and c-Kit (IC50’s 95-122 ng/ml). It inhibits FLT3 phosphorylation, downstream signaling and tumor growth in...

Tangeretin | B3350Description: Tangeretin is a methoxyflavone compound isolated from citrus fruits that demonstrates antiproliferative and antioxidant effects. It inhibits signaling in cancer cells,...

3348 | TANK Antibody DataSheet

3348BP | TANK Blocking Peptide DataSheetAntibody Target: TANK Accession #: Q92844Gene ID: 10010Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

Sodium tanshinone IIA sulphonate (T06) is a water-soluble derivative of tanshinone IIA, that displays versatile biological properties. Recently, it has been shown to act as an ectosteric inhibitor of...

3776 | TAOK1 Antibody DataSheet

3776RBP | TAOK1 Blocking Peptide DataSheetAntibody Target: TAOK1 Accession #: EDM05292Gene ID: 286993Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Inhibitor of TNF-α processing (IC₅₀ = 100 nM). Inhibits TACE (ADAM17) and other metalloproteases with Ki (nM) values of 8.8, 17, 6, 68, 0.5 and 0.2 for TACE, MDC9 (ADAM9), MMP-1, MMP-3, MMP-9 and...

Inhibitor of TNF-α processing (IC₅₀ = 100 nM), similar to TAPI-0 (Cat. No. 2067-1), but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- α...

A broad spectrum inhibitor of MMPs and ADAMs (proteins containing A Disintegrin and A Metalloprotease domain). This inhibitor has been used in tissue culture (typical concentration 5-100 μM).TAPI-2...

Taq DNA Ligase catalyzes the formation of a phosphodiester bond between 5ʹ- phosphate and 3ʹ- hydroxyl groups of adjacent DNA strands annealed to their complement strand. The enzyme only repairs the...

7018 | Taq DNA Polymerase Polyclonal Antibody DataSheet

Taq DNA Polymerase is a thermostable enzyme that replicates DNA and exhibits a half-life of 40 minutes at 95°C. Taq catalyzes the polymerization of nucleotides into duplex DNA in the 5’ –3’ direction...

2X QPCR Master MixM1121 | Taqman Master Mix DataSheetSort Name: Taqman Master MixLabel Name: Taqman Master MixTaglines: 2X QPCR Master MixProduct Highlights: 2X QPCR Master MixPackaging: Set (4)

2X QPCR Master MixM1122 | Taqman Master Mix-iCycler DataSheetSort Name: Taqman Master Mix-iCyclerLabel Name: Taqman Master Mix-iCyclerTaglines: 2X QPCR Master MixProduct Highlights: 2X QPCR Master...

Taqman Master Mix-Low ROX | M1123

2X QPCR Master MixM1125 | Taqman Master Mix-Multiplex DataSheetSort Name: Taqman Master Mix-MultiplexLabel Name: Taqman Master Mix-MultiplexTaglines: 2X QPCR Master MixProduct Highlights: 2X QPCR...

2X QPCR Master MixM1124 | Taqman Master Mix-ROX DataSheetSort Name: Taqman Master Mix-ROXLabel Name: Taqman Master Mix-ROXTaglines: 2X QPCR Master MixProduct Highlights: 2X QPCR Master MixPackaging:...

Taqman QRT Kit | M1183

One-Step Taqman QRT PCR KitM1184 | Taqman QRT Kit-iCycler DataSheetSort Name: Taqman QRT Kit-iCyclerLabel Name: Taqman QRT Kit-iCyclerTaglines: One-Step Taqman QRT PCR KitProduct Highlights: One-Step...

One-Step Taqman QRT PCR KitM1185 | Taqman QRT Kit-Low ROX DataSheetSort Name: Taqman QRT Kit-Low ROXLabel Name: Taqman QRT Kit-Low ROXTaglines: One-Step Taqman QRT PCR KitProduct Highlights: One-Step...

One-Step Taqman QRT PCR KitM1186 | Taqman QRT Kit-ROX DataSheetSort Name: Taqman QRT Kit-ROXLabel Name: Taqman QRT Kit-ROXTaglines: One-Step Taqman QRT PCR KitProduct Highlights: One-Step Taqman QRT...

Human TARC is a recently discovered protein belonging to the -chemokine (C-C) family of cytokines. It has been shown that TARC is chemotactic towards T-cells but ineffective on monocytes. The...

Targocil is a novel antibiotic that inhibits a late acting step in the WTA (Wall teichoic acid) pathway. WTAs are phosphate-rich, sugar-based polymers attached to the cell walls of most Gram-positive...

Tariquidar is a potent, specific, noncompetitive inhibitor of P-glycoprotein (P-gp) (Kd = 5.1 nM). Tariquidar inhibits the ATPase activity of P-gp, suggesting that the modulating effect is derived...

TAS-103 (BMS-247615) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topo II).TAS-103 (BMS-247615) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topo II)...

TAS-109 is a novel deoxycitidine analog that inhibits DNA polymerase resulting in S-phase arrest, while prolonged exposure to TAS-109 at low concentration causes DNA fragmentation, G2/M phase arrest...

TAS-120 is a novel, potent and highly selective FGFR inhibitor that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations. It blocks the phosphorylation of FGFRs and impedes...

TAS-301 is an inhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon...

Tasimelteon is a potent Dual Melatonin Receptor Agonist (DMRA). It is used to treat non-24-hour sleep-wake disorder. The Ki values for binding affinity at melatonin receptors MT1 and MT2 receptor are...

TASIN-1 (Truncated APC Selective INhibitor-1) is a novel truncated APC selective inhibitor, selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol...

Tasquinimod has anti-angiogenic, antitumor and immune-modulatory properties. It shows consistent anti-angiogenic activity in vitro at doses between 10-50 μM. The mechanism of action of tasquinimod is...

K4263 | Tau / MAPT Human Elisa Kit DataSheet

3549RBP | Tau Blocking Peptide DataSheetAntibody Target: Tau Accession #: EDM06298Gene ID: 29477Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3453 | Anti-Tau-13 Antibody DataSheet

Tau is a microtubule-associated protein involved in Alzheimer’s and Parkinson’s disease. It promotes microtubule assembly and stability, and might participate in the establishment and maintenance of...

K988 | Taurine Assay Kit Colorimetric DataSheet

Taurocholic acid sodium is a bile acid conjugate with detergent properties. This anionic detergent is useful for the solubilization of lipids and membrane-bound proteins.Taurocholic acid sodium is a...

Tautomycin is a potent protein phosphatase inhibitor that inhibits PP1 completely at 3 nM and PP2 at 30 nM. Acts as a weak inhibitor of PP2B and does not inhibit PP2C. Its cell permeability and...

Tavaborole (AN2690) is a potent, broad-spectrum antifungal agent that targets the post-transfer editing site of leucyl-tRNA synthetase (LeuRS). Tavaborole forms a covalent adduct with the 3′...

Tazarotene is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis, acne vulgaris and photoaging. Tazarotene induces the expression of tazarotene-induced gene 3...

3699BP | TBLR1 Blocking Peptide DataSheetAntibody Target: TBLR1 Accession #: AAK00301Gene ID: 79718Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

TBPB is a highly selective allosteric Muscarinic M1 agonist (EC₅₀ = 289 nM). TBPB increases non-amyloidogenic APP processing and produces antipsychotic-like effects in rodent models predictive of...

TC-E 5002 is an inhibitor of the histone lysine demethylase (KDM) subfamily KDM2/7. It potently inhibits KDM2A, KDM7A and KDM7B with an IC₅₀ of 6.8 μM, 0.2 μM and 1.2 μM respectively. It inhibits the...

TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 1.5 μM); displays no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a...

TC-H 106 is a class I Histone deacetylase (HDAC) inhibitor with IC₅₀ values of 150,370,760 and 5000 nM for HDAC1, 3, 2 and 8 respectively. TC-H 106 shows slow and tight binding inhibitory activity on...

TC-S 7010 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ = 3.4 nM). It displays1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in...

TCE35031 is an analog of Thalidomide (Cat. No. 2020) commonly used as a precursor to PROTACs (proteolysis-targeting chimera technologies) that hijack cereblon as the E3 ubiquitin ligase component...

A 1 M solution of TCEP hydrochloride (Cat. No. 1202) in water. TCEP hydrochloride is an odorless, thiol-free reagent useful for the selective reduction of disulfides. Compared to DTT, TCEP is more...

A water-soluble, odorless, thiol-free reagent useful for the selective reduction of disulfides. Compared to DTT, TCEP is more stable, more effective and able to reduce disulfide bonds at lower pHs...

3090 | TCF3/E2A Antibody DataSheet

3090BP | TCF3/E2A Blocking Peptide DataSheetAntibody Target: TCF3/E2AAccession #: D4ABE2 Gene ID: Rn.12922. Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

Cell-permeable. A potent and selective inhibitor of ubiquitin C-terminal hydrolase L3 (UCH-L3) (IC50 = 0.6 µM). Inhibits ubiquitin C-terminal hydrolase L1 (UCH-L1) only at higher concentrations (IC50...

5648 | TCR alpha Antibody DataSheet

5648BP | TCR alpha Blocking Peptide DataSheetAntibody Target: TCR alphaAccession #: 18195Gene ID: 171558Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

5651 | TCR beta Antibody DataSheet

5651BP | TCR beta Blocking Peptide DataSheetAntibody Target: TCR beta Accession #: P01850Gene ID: 28639Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

TCS 21311 is a potent JAK3 (Janus kinase 3) inhibitor. It shows high selectivity for JAK3 over JAK1, JAK2 and TYK2 with IC₅₀ values of 8 nM, 1017 nM, 2550 nM and 8055 nM respectively. It also...

TCS 5861528 is a selective transient receptor potential ankyrin 1 (TRPA1) blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal with IC₅₀ values...

TCS HDAC6 20b is an inhibitor of histone deacetylase 6 (HDAC6). It synergistically inhibits the growth of HCT116 cells at a concentration of 5 µM in combination with paclitaxel. It blocks the growth...

TCS JNK 5a (JNK Inhibitor IX) is a selective inhibitor of JNK2 and JNK3; displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0)...

TCS OX2 29 is a potent and selective OX2 (Orexin-2) receptor antagonist (IC₅₀ = 40 nM). Displays >250-fold selectivity for OX2 over OX1 (Orexin-1) and >50 receptors, ion channels and transporters.TCS...

TCS PIM-1 1 is a potent, ATP-competitive Pim-1 kinase inhibitor (IC₅₀ = 50 nM). Displays high selectivity over Pim-2 and MEK1/2 (IC₅₀ >20 µM).TCS PIM-1 1 is a potent, ATP-competitive Pim-1 kinase...

TCS-1102 | B3360Description: TCS-1102 is a potent, brain-permeable dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively. It is a poor substrate for...

TCS-359 is a potent, ATP-competitive inhibitor of FLT3 receptor tyrosine kinase (IC₅₀ = 42 nM) that displays selectivity over a range of other kinases. It blocks the proliferation of myelomonocytic...

3087 | TCTN1 antibody DataSheet

3087BP | TCTN1 Blocking Peptide DataSheetAntibody Target: TCTN1Accession #: Q05BR9Gene ID: Hs.211511. Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3088BP | TCTN1 Blocking Peptide DataSheetAntibody Target: TCTN1Accession #: Q05BR9Gene ID: Hs.211511. Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3262 | TCTN2 Antibody DataSheet

3262BP | TCTN2 Blocking Peptide DataSheetAntibody Target: Tectonic-2Accession #: Q3B7D3Gene ID: 689779Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3333 | TCTN3 Antibody DataSheet

Antibody Target: TCTN3Accession #: Q8R2Q6Gene ID: 67590Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1%...

TD-139 is a potent, synthetic inhibitor of galectin-3. TD-139 has high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or...

6157 | TDG Antibody DataSheet

Teratocarcinoma-derived growth factor 1, also known as epidermal growth factor-like cripto protein CR1, CRGF, and TDGF1, is a cell membrane which contains one EGF-like domain. In humans, TDGF1 is...

6698 | TDP1 Antibody (Clone AT1F2) DataSheet

6697 | TDP2 Antibody DataSheet

Tudor domains are small protein structural motifs of about ~50 amino acids related to the “royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor...

6664 | TDRD12-BD2 Antibody DataSheet