ADAMTS5 Antibody (Center) [APR32443G]

ADAMTS5 Antibody (Center) [APR32443G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This ADAMTS5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-360 amino acids from the Central region of human ADAMTS5.

Cellular Localisation: Secreted, extracellular space, extracellular matrix

Molecular Weight: 101718

Clone: Polyclonal

Gene Name: ADAMTS5

Gene ID: 11096

Function: Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360) . Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity) . Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity) . Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.

Summary: Tissue Location: Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, 3424-, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAM-TS 11, ADAMTS-11, ADMP-2, Aggrecanase-2, ADAMTS5, ADAMTS11, ADMP2