ALK (phospho Tyr1096) Antibody | 79-840

ALK (phospho Tyr1096) Antibody | 79-840 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: ALK (phospho Tyr1096) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1096 (P-N-Y (p) -C-F) derived from Human ALK.

Research Area: Phospho-Specific

Tested Application: IHC

Application: N/A

Specificiy: The antibody detects endogenous levels of ALK only when phosphorylated at tyrosine 1096.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 176 kDa

Validation: N/A

Isoform: N/A

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+) , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Concentration: 1 mg/mL

Storage Condition: Store antibody at -20˚C for up to one year.

Alternate Name: ALK tyrosine kinase receptor, anaplastic lymphoma kinase, anaplastic lymphoma kinase (Ki-1) , CD246; EC 2.7.10.1, kinase ALK

User Note: N/A

BACKGROUND: The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs) . The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain.