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Alpha 2 Macroglobulin, Human Plasma, Fast Form | 7297
- SKU:
- 26-7297-GEN
- Availability:
- Usually shipped in 5 working days
Description
Alpha 2 Macroglobulin (A2M) is a plasma protease inhibitor which has been shown to exist in two forms. The Slow Form of A2M (S-A2M) is the form which possesses the ability to bind and inhibit proteases by a trap method. The Fast Form of A2M (F-A2M) is generated when S-A2M undergoes a conformational change due to either entrapment of a protease in the A2M bait region, or chemical cleavage of an internal thiol ester bond located near the bait region. F-A2M does not possess the ability to bind and inhibit protease activity. F-A2M is rapidly taken up by the liver, with a half-life of 2-4 minutes. In vivo, F-A2M typically represents only 0.170.7% of the total A2M in blood plasma of adults. The F-A2M plasma concentration is, however, increased in many disease states including pancreatitis, multiple sclerosis and sepsis. F-A2M has also been implicated in the inhibition of amyloid formation associated with Alzheimers disease and spongiform encephalopathy.
7297 | Alpha 2 Macroglobulin Human Plasma Fast Form DataSheet
Biomolecule/Target: Alpha 2 Macroglobulin
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5, FWP007
Alternates names: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5, FWP007
Taglines: A broad-spectrum protease-binding protein
NCBI Gene ID #: 2
NCBI Gene Symbol: A2M
Gene Source: Human
Accession #: P01023
Recombinant: No
Source: Human Plasma
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 725 kDa (Homotetramer, Subunit size: 180 kDa)
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 100 mM Na Phosphate, pH 7.2.
Reconstitution Instructions: In water or aqueous buffer
Amino acid sequence: N/A