Anti- androgen receptor Antibody | FNab10391

Anti- androgen receptor Antibody | FNab10391 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease) . Mutations in this gene are also associated with complete androgen insensitivity (CAIS) . Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen: androgen receptor

synonyms: AIS, androgen receptor, AR, DHTR, Dihydrotestosterone receptor, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM

Molecular weight (observed) : 45 kDa, 75-80 kDa

Reactivity Species: Human, rat

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:500-1:2000

Research Area: Signal Transduction, Metabolism, Cancer, Immunology, Neuroscience