Anti-Caspase-3 Antibody | A1751

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

A1751 | Anti-Caspase-3 Antibody DataSheet

Antibody Target: Caspase-3

Target Alternative Name: CASP3, Caspase 3, apoptosis-related cysteine protease, CPP32B, Cysteine protease CPP32, SCA-1, SREBP cleavage activity 1

Tag Line: Polyclonal antibody to detect Caspase-3 in human mouse and rat sample.

Category: Neuroscience

Host: Rabbit

Isotype: IgG

Species Reactivities: Rat, Mouse, Human

Immunogen Sequence: Recombinant protein of human CASP3

Accession #: P42574

Gene ID: 836

Appearance: Colorless liquid

Form: Liquid

Concentration: 0.6 mg/ml

Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3

Purification: Affinity purification

Application: Immunohistochemistry (IHC), Western Blotting, ELISA

Positive Control:

Application And Usages: WB 1:200-1:1000, IHC 1:50-1:200

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: True

Immunocytochemistry Verified: True

Immunofluorescence Verified: False

Immunoprecipitation Verified: False

FACS Verified: False

ELISA Verified: False

ChIP Verified: False

Dot Blot Verified: False

Flow Cytometry Verified: False