Anti-Citrullinated Myelin Basic Protein Polyclonal Antibody | A2320

Myelin basic protein (MBP) comprises several isoforms of a single gene product, which together make up a major component of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system. MBP contains 19 arginine residues that can be citrullinated by protein arginine deiminases (PADs), which will decrease the positive charge of the protein. The decrease in positive charge disrupts MBP interactions with the lipid membranes of myelin sheath cells. Citrullinated MBP is associated with demyelination and multiple sclerosis.

A2320 | Anti-Citrullinated Myelin Basic Protein Polyclonal Antibody DataSheet

Antibody Target: Citrullinated human myelin basic protein

Target Alternative Name: Myelin Membrane Encephalitogenic Protein; Myelin A1 Protein; Proline-Rich Proteoglycan 2; Golli-MBP; MBP

Tag Line: An autoimmune biomarker in multiple sclerosis

Category: GM-CSF

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Human

Immunogen Sequence: Synthetic peptide derived from human myelin basic protein (isoform 5) citrullinated at R122 and R130

Accession #: P02686

Gene ID: 4155

Appearance: Liquid

Form: Rabbit polyclonal

Concentration:

Formulation: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide

Purification: Peptide affinity purification

Application: ELISA Western Blotting

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: TRUE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE