Anti-FGF21 Antibody (Clone# ARC0865) | A2237

Fibroblast growth factor 21 (FGF21) is a pleiotropic hormone that belongs to the fibroblast growth factor family that has multifaceted roles in biological processes such as angiogenesis, metabolism, embryonic development, and tumor growth and invasion. FGF21 is expressed in multiple tissues such as the liver, adipose tissue, pancreas, brain, and gastrointestinal tract. FGF21 is known as a major regulator of glucose and lipid metabolism. Under nutritional stress conditions (fasting, caloric restriction, ketogenic diets), FGF21 stimulates the production of glucose in the liver via gluconeogenesis. In the adipose tissue, it increases the uptake of glucose by stimulating the expression of GLUT1. FGF21 promotes weight loss without decreasing the intake of food, decreases the fat content in the liver, and reduces triglyceride and glucose concentrations in the blood plasma. Due to its beneficial role in energy homeostasis and metabolism, FGF21 has been proposed as a therapeutic target for metabolic disorders.

A2237 | Anti-FGF21 Antibody (Clone# ARC0865) DataSheet

Antibody Target: FGF21

Target Alternative Name: Fibroblast Growth Factor 21, FGF-21, FGF21, FGF 21

Tag Line: Rabbit monoclonal antibody that detects the expression of FGF21 in human, mouse, and rat samples

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Rat,Mouse,Human

Immunogen Sequence: Synthetic peptide derived from human FGF21

Accession #: Q9NSA1

Gene ID: 26291

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH 7.3

Purification: Affinity purified

Application: Immunohistochemistry (IHC),Western Blotting

Positive Control:

Application And Usages: WB 1:500 - 1:2000, IHC 1:50 - 1:200

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: TRUE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE