26
Anti-Toxin B (Bezlotoxumab), Human IgG1 Antibody | A2220
- SKU:
- 26-A2220-100-GEN
- Availability:
- Usually shipped in 5 working days
Description
The research-grade biosimilar is a human monoclonal antibody that targets Clostridium difficile toxin B. Toxin B (TcdB) is a glucosyltransferase protein that glucosylates small GTPases such as Rho, Rac, and Cdc42 in the target cells. The toxin is known to disrupt the actin cytoskeleton of the cells by causing condensation of the actin, blebbing of the membrane, which eventually leads to apoptosis and cell death. The antibody binds to the two epitopes on the N-terminal of the Toxin B CROP domain via its two Fab regions, thus partially blocking carbohydrate-binding pockets and prevents the binding of the toxin to the host cells. The original monoclonal antibody was approved by the FDA to treat adult patients who are either receiving antibacterial treatment for Clostridium difficile infection (CDI) or are at a high risk of getting re-infected with CDI
A2220 | Anti-Toxin B (Bezlotoxumab), Human IgG1 Antibody DataSheet
Antibody Target: Toxin B
Target Alternative Name: MBL-CDB1, MK-6072, CDB-1, MDX-1388, MK-3415A, tcdB, glycosylating toxin TcdB
Tag Line: The biosimilar is a human monoclonal antibody that targets and inhibits the binding of Clostridium difficile toxin B to mammalian host cells
Category: Biosimilars
Host: Recombinant
Isotype: IgG1, kappa
Species Reactivities: Clostridium difficile
Immunogen Sequence: Clostridium difficile Toxin B
Accession #: P18177/DB13140
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
Additional Information
Size: |
100 ug |
Storage Condition: |
-80ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |