Anti-Toxin B (Bezlotoxumab), Human IgG1 Antibody | A2220

The research-grade biosimilar is a human monoclonal antibody that targets Clostridium difficile toxin B. Toxin B (TcdB) is a glucosyltransferase protein that glucosylates small GTPases such as Rho, Rac, and Cdc42 in the target cells. The toxin is known to disrupt the actin cytoskeleton of the cells by causing condensation of the actin, blebbing of the membrane, which eventually leads to apoptosis and cell death. The antibody binds to the two epitopes on the N-terminal of the Toxin B CROP domain via its two Fab regions, thus partially blocking carbohydrate-binding pockets and prevents the binding of the toxin to the host cells. The original monoclonal antibody was approved by the FDA to treat adult patients who are either receiving antibacterial treatment for Clostridium difficile infection (CDI) or are at a high risk of getting re-infected with CDI

A2220 | Anti-Toxin B (Bezlotoxumab), Human IgG1 Antibody DataSheet

Antibody Target: Toxin B

Target Alternative Name: MBL-CDB1, MK-6072, CDB-1, MDX-1388, MK-3415A, tcdB, glycosylating toxin TcdB

Tag Line: The biosimilar is a human monoclonal antibody that targets and inhibits the binding of Clostridium difficile toxin B to mammalian host cells

Category: Biosimilars

Host: Recombinant

Isotype: IgG1, kappa

Species Reactivities: Clostridium difficile

Immunogen Sequence: Clostridium difficile Toxin B

Accession #: P18177/DB13140

Gene ID:

Appearance: Colorless liquid

Form: Liquid

Concentration: 1 mg/ml

Formulation: In PBS, pH 7.5

Purification: Protein A purified

Application:

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE