710
Anti- WTAP Antibody | FNab09530
- SKU:
- 710-FNab09530-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- WTAP Antibody | FNab09530 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Protein A+G purification
Purity: ≥95% as determined by SDS-PAGE
Host: Mouse
Clonality: monoclonal
Clone ID: 9D4
Isotype: IgG1
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863) . Acts as a mRNA splicing regulator (PubMed:12444081) . Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532) . Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724) .
Immunogen: Wilms tumor 1 associated protein
synonyms: DKFZp686F20131, Female lethal (2) D homolog, hFL (2) D, KIAA0105, WT1 associated protein, WTAP
Molecular weight (observed) : 49 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IP, WB
Recomended Dillution : WB: 1:1000-1:10000; IHC: 1:50-1:500
Research Area: Epigenetics