Anti- WTAP Antibody | FNab09530

Anti- WTAP Antibody | FNab09530 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Protein A+G purification

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 9D4

Isotype: IgG1

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863) . Acts as a mRNA splicing regulator (PubMed:12444081) . Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532) . Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724) .

Immunogen: Wilms tumor 1 associated protein

synonyms: DKFZp686F20131, Female lethal (2) D homolog, hFL (2) D, KIAA0105, WT1 associated protein, WTAP

Molecular weight (observed) : 49 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, IP, WB

Recomended Dillution : WB: 1:1000-1:10000; IHC: 1:50-1:500

Research Area: Epigenetics