Bax Antibody| F40098-0.08ML/F40098-0.4ML/R32761/V2005-20UG/V2005IHC-7ML

Bax Antibody| F40098-0.08ML/F40098-0.4ML/R32761/V2005-20UG/V2005IHC-7ML | Gentaur UK, US & Europe Distribution

Background: Bax belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bax forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of the Bax gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Bovine

Application: FACS, WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100, Flow Cytometry: 1:10-1:50

Application Note: Titration of the Bax antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This Bax antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 41-76 (BH3 domain) from the human protein was used as the immunogen for this Bax antibody.

Storage: Aliquot the Bax antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A