BGLAP Antibody | 15-643

BGLAP Antibody | 15-643 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BGLAP (NP_954642.1) .

Research Area: Cell Cycle, Signal Transduction, Stem Cell

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: U-251MG

Positive Control 2: Mouse pancreas

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 11kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: BGLAP, bone gamma-carboxyglutamate (gla) protein, BGP, OC, OTTHUMP00000016586, bone Gla protein, bone gamma-carboxyglutamate (gla) protein (osteocalcin) , gamma-carboxyglutamic acid-containing protein, osteocalcin

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1) , but the encoded protein only shows sequence identity with the upstream gene product.