CACNA1H Antibody | 8029

CACNA1H Antibody | 8029 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: CACNA1H antibody was raised against a 16 amino acid peptide near the center of human CACNA1H.
The immunogen is located within amino acids 1010 - 1060 of CACNA1H.

Research Area: Neuroscience

Tested Application: E, WB, IHC-P, IF

Application: CACNA1H antibody can be used for detection of CACNA1H by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Specificiy: CACNA1H antibody is human, mouse and rat reactive. Multiple isoforms of CACNA1H are known to exist.

Positive Control 1: Cat. No. 1210 - HEK293 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 259 kDa
Observed: 260 kDa

Validation: N/A

Isoform: N/A

Purification: CACNA1H antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: CACNA1H antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: CACNA1H antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Calcium channel voltage-dependent T type alpha 1H subunit, CACNA1HB, Cav3.2, ECA6, EIG6

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The calcium channel protein CACNA1H is a T-type member of the alpha-1 subunit family that is part of the voltage-dependent calcium channel complex which mediates the influx of calcium ions into the cell upon membrane polarization (1, 2) . CACNA1H is a subunit of Cav3.2 T-type calcium channel that is involved in neurological disorders such as epilepsy and pain (2, 3) . CACNA1H associates with the caveolin protein Cav-3 and it is thought that Cav-3 regulates the Protein Kinase A (PKA) modulation of CACNA1H-containing Cav3.2 T-type calcium channels (4) .