Carboxylesterase Activity Assay Kit (Fluorometric) - K2014

K2014 | Carboxylesterase Activity Assay Kit (Fluorometric) DataSheet

Human Carboxylesterase 1 (E.C. 3.1.1.1, CES1, hCE1, CES1b or CES1A1) is a α,β-serine hydrolase expressed in most tissues with higher levels in the liver. It plays a crucial role in the metabolism of various ester xenobiotics including many ester drugs (such as oseltamivir, clopidogrel, irinotecan and capecitabine) and environmental toxicants (such as pyrethroids). Additionally, Carboxylesterases are known to metabolize endogenous esters including triacylglycerols, cholesteryl esters, and other endogenous lipids thereby maintaining lipid homeostasis. More specifically, Carboxylesterases catalyze the ester cleavage of a large number of diverse ester- or amide-containing substrates into alcohol and carboxylic acid. ’s Carboxylesterase Activity Assay Kit is a simple, rapid, plate-based fluorometric assay for measuring Carboxylesterase activity in biological samples. The kit uses the proprietary substrate for the quantification of Carboxylesterase (CE) activity in samples. The assay can detect as low as 6.6 µU of Carboxylesterase activity.

Alternate Name : Carboxylesterase Fluorometric Activity Assay Kit, Carboxylesterase Activity Assay, Carboxylesterase Fluorometric Activity Kit, Carboxylesterase Activity Assay Kit, Carboxylesterase Fluorometric Assay, Carboxylesterase Activity Assay, Carboxylesterase Activity Assay (Fluorometric), Carboxylesterase Fluorometric Activity Assay, Carboxylesterase, Carboxylesterase Fluorometric Assay Kit, Carboxylesterase Activity Kit (Fluorometric), Carboxylesterase Activity Kit, Carboxylesterase Assay Kit, Carboxylesterase Activity (Fluorometric), Carboxylesterase Activity Assay Kit, Carboxylesterase Fluorometric Activity Kit, Carboxylesterase Activity Kit, Carboxylesterase Fluorometric Activity Assay, Carboxylesterase Activity Assay Kit (Fluorometric)

Tag Line : for measuring Carboxylesterase activity in biological samples

Summary : Human Carboxylesterase 1 (E.C. 3.1.1.1, CES1, hCE1, CES1b or CES1A1) is a α,β-serine hydrolase expressed in most tissues with higher levels in the liver. It plays a crucial role in the metabolism of various ester xenobiotics including many ester drugs (such as oseltamivir, clopidogrel, irinotecan and capecitabine) and environmental toxicants (such as pyrethroids). Additionally, Carboxylesterases are known to metabolize endogenous esters including triacylglycerols, cholesteryl esters, and other endogenous lipids thereby maintaining lipid homeostasis. More specifically, Carboxylesterases catalyze the ester cleavage of a large number of diverse ester- or amide-containing substrates into alcohol and carboxylic acid. ’s Carboxylesterase Activity Assay Kit is a simple, rapid, plate-based fluorometric assay for measuring Carboxylesterase activity in biological samples. The kit uses the proprietary substrate for the quantification of Carboxylesterase (CE) activity in samples. The assay can detect as low as 6.6 µU of Carboxylesterase activity.

Detection Method : Fluorescence (Ex/Em = 490/550 nm)

Sample Type : Cell Culture (i.e. HepG2 cell lysate), Mammalian Tissues (i.e. rat and human liver microsomes, S9 fraction)

Species Reactivity : All

Applications : Carboxylesterase activity in cell or tissue lysates

Features and Benefits : Simple, Plate-based fluorometric assay for measuring Carboxylesterase activity in biological samples, Rapid