Description
α-GalCer is a specific ligand for human and mouse natural killer T (NKT) cells; exhibits potent anti-tumor activity with murine in vivo experiments including subcutaneous implanted model and metastatic models in the liver and lung. KRN7000 has been reported to show various immunological effects in infectious diseases, autoimmune disease and graft verse host disease in mice.
α-GalCer is a specific ligand for human and mouse natural killer T (NKT) cells; exhibits potent anti-tumor activity with murine in vivo experiments including subcutaneous implanted model and metastatic models in the liver and lung. KRN7000 has been reported to show various immunological effects in infectious diseases, autoimmune disease and graft verse host disease in mice.
2152 | α-Galactosylceramide DataSheet
Alternate Name/Synonyms: alpha-Galactosylceramide; αGalCer; KRN7000; (2S,3S,4R)-1-O-(α-D-galactosyl)-N-hexacosanoyl-2-amino- 1,3,4-octadecanetriol
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 158021-47-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₅₀H₉₉NO₉
Molecular Weight: 858.32
Cell-Permeable?: No
Purity: ≥96% by NMR
Solubilities: For In vivo assay: Use 5.6% sucrose, 0.75% L-histidine and 0.5% Tween20 with heating at 60-80 ̊C. For In vitro assay: should be dissolved in DMSO at the concentration of 1 mg/ml with heating at 60-80 ̊C . The solution of 1mg/ml in DMSO can be diluted by PBS.
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A specific ligand for human and mouse natural killer T (NKT) cells
MDL Number: MFCD00939559
PubChem CID: 2826713
SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)O)O)O)C(C(CCCCCCCCCCCCCC)O)O
InChi: InChI=1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42-,43+,44+,46-,47-,48-,49+,50-/m0/s1
InChi Key: VQFKFAKEUMHBLV-BYSUZVQFSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24months |