HVCN1 Antibody | 5875

HVCN1 Antibody | 5875 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Chicken: (71%)

Immunogen: HVCN1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human HVCN1.
The immunogen is located within the last 50 amino acids of HVCN1.

Research Area: Immunology

Tested Application: E, WB, IHC-P, IF

Application: HVCN1 antibody can be used for detection of HVCN1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human and mouse samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Specificiy: N/A

Positive Control 1: Cat. No. 1406 - Mouse Spleen Tissue Lysate

Positive Control 2: Cat. No. 1306 - Human Spleen Tissue Lysate

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 30 kDa
Observed: 30 kDa

Validation: N/A

Isoform: N/A

Purification: HVCN1 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: HVCN1 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: HVCN1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: HVCN1 Antibody: HV1, VSOP, UNQ578/PRO1140, Voltage-gated hydrogen channel 1, Hydrogen voltage-gated channel 1, HV1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: HVCN1 Antibody: HVCN1 (hydrogen voltage-gated channel 1) , a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 may represent a new therapeutic target for B cell malignancies on continued signaling via the B cell antigen receptor.