LAMTOR2 Antibody | 7711

LAMTOR2 Antibody | 7711 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Bovine: (100%)

Immunogen: LAMTOR2 antibody was raised against an 18 amino acid peptide near the center of human LAMTOR2.
The immunogen is located within amino acids 40 - 90 of LAMTOR2.

Research Area: Homeostasis

Tested Application: E, WB, IHC-P, IF

Application: LAMTOR2 antibody can be used for detection of LAMTOR2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: LAMTOR2 antibody is human, mouse and rat reactive. At least two isoforms of LAMTOR2 are known to exist; this antibody will detect both isoforms. LAMTOR2 antibody is predicted to not cross-react with other LAMTOR family proteins.

Positive Control 1: Cat. No. 1211 - HepG2 Cell Lysate

Positive Control 2: Cat. No. 10-901 - Human Spleen Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 14 kDa
Observed: 16 kDa

Validation: N/A

Isoform: N/A

Purification: LAMTOR2 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: LAMTOR2 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: LAMTOR2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: LAMTOR2 Antibody: p14, ENDAP, ROBLD3, HSPC003, MAPBPIP, MAPKSP1AP, Ragulator2, Ragulator complex protein LAMTOR2, Endosomal adaptor protein p14, MAPBP-interacting protein

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The late endosomal/lysosomal adaptor MAPK and MTOR activator 2 (LAMTOR2) protein belongs to the LAMTOR family of proteins, and together with LAMTOR3 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling (1, 2) . This complex is involved in the regulation of late endosomal traffic and cellular proliferation (3) and plays a role in cellular host defense against Salmonella infection (4) .