mGluR-2/3 (N867) polyclonal Antibody | BS3430

mGluR-2/3 (N867) polyclonal Antibody | BS3430 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors) . The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: mGluR-2/3 (N867) polyclonal Antibody detects endogenous levels of mGluR-2 and mGluR-3 protein

Molecular Weight: ~ 95 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Metabotropic glutamate receptor 2; mGluR2; GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 3; mGluR3; GRM3; GPRC1C; MGLUR3

Immunogen: Synthetic peptide, corresponding to amino acids 836-886 of Human mGluR-2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Phospholipase Signaling,Regulation of Microtubule Dynamics,G Protein-coupled Receptors Signaling to MAPK Erk,ErbB HER Signaling,