Mouse Camk2a Antibody (C-term) [APR04012G]

Mouse Camk2a Antibody (C-term) [APR04012G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This Mouse Camk2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-349 amino acids from the C-terminal region of mouse Camk2a.

Cellular Localisation: [Isoform Alpha KAP]: Cytoplasm

Molecular Weight: 54115

Clone: Polyclonal

Gene Name: Camk2a

Gene ID: 12322

Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca (2+) /calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity) . Regulates dendritic spine development. Also regulates the migration of developing neurons (By similarity) . Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378) . Acts as a negative regulator of 2- arachidonoylglycerol (2-AG) -mediated synaptic signaling via modulation of DAGLA activity (PubMed:23502535) .

Summary: Tissue Location: [Isoform Alpha CaMKII]: Expressed in brain.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, Camk2a