α-naphthoflavone | 2918

Potent and selective inhibitor of CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50 = 500, 60, 6, and 5 nM respectively). Can activate CYP3A4 (Kd = 7.4 µM).

Potent and selective inhibitor of CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50 = 500, 60, 6, and 5 nM respectively). Can activate CYP3A4 (Kd = 7.4 µM).

2918 | α-naphthoflavone DataSheet

Alternate Name/Synonyms: 2-phenyl-4H-naphtho[1,2-b]pyran-4-one, NSC 407011, 7,8-Benzoflavone

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 604-59-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₂O₂

Molecular Weight: 272.3

Cell-Permeable?: N/A

Purity: ≥98%

Solubilities: DMSO (~10 mg/ml) or DMF (~20 mg/ml), Ethanol (~1 mg/ml)

Handling: Protect from air, light and moisture

Country of Origin: USA

Tag Line: A potent inhibitor of Cytochrome P450 enzymes (Aromatase, 1A2, 1A1, 1B1)

MDL Number: MFCD00004985

PubChem CID: 11790

SMILES: O=C1C2=C(C(C=CC=C3)=C3C=C2)OC(C4=CC=CC=C4)=C1

InChi: InChI=1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H

InChi Key: VFMMPHCGEFXGIP-UHFFFAOYSA-N