Poziotinib | 9519

Poziotinib is an irreversible Pan-HER inhibitor with IC₅₀s of 3 nM, 5 nM and 23 nM for HER1, HER2, and HER4 respectively. Displays antineoplastic activity.

Poziotinib is an irreversible Pan-HER inhibitor with IC₅₀s of 3 nM, 5 nM and 23 nM for HER1, HER2, and HER4 respectively. Displays antineoplastic activity.

9519 | Poziotinib DataSheet

Alternate Name/Synonyms: 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one; HM781-36B; NOV120101

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1092364-38-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₁Cl₂FN₄O₃

Molecular Weight: 491.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A an irreversible Pan-HER inhibitor

MDL Number: N/A

PubChem CID: 25127713

SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C

InChi: InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)

InChi Key: LPFWVDIFUFFKJU-UHFFFAOYSA-N