PP242 | 1658

A potent and selective in vitro mTOR inhibitor that targets the ATP domain of mTOR (IC₅₀ = 8 nM). Inhibits other PI 3-Kinases only at much higher concentrations. Recently it has been shown that PP242 is a more effective mTORC1 inhibitor than Rapamycin (Cat. No. 1568-5 & 1568-50).

PP242 is a potent and selective in vitro mTOR inhibitor that targets the ATP domain of mTOR (IC₅₀ = 8 nM). Inhibits other PI 3-Kinases only at much higher concentrations.

1658 | PP242 DataSheet

Alternate Name/Synonyms: 2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1092351-67-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₆N₆O

Molecular Weight: 308.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A mTOR inhibitor

MDL Number: MFCD12196869

PubChem CID: 25243800

SMILES: CC(C)N1C2=C(C(=C3C=C4C=C(C=CC4=N3)O)N1)C(=NC=N2)N

InChi: InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,21,23H,1-2H3,(H2,17,18,19)/b14-12+

InChi Key: MTICIDWIKCANDD-WYMLVPIESA-N