PPACK II, trifluoroacetate | B2151

PPACKII is a specific and irreversible inhibitor of glandular and plasma kallikreins. Human tissue kallikreins (hKs) are a class of secreted serine proteases that involved in the release of vasodepressor peptides or kinins from a plasma substrate. Kallikreins have been implicated in many cancer-related processes, such as cell-growth regulation, angiogenesis, invasion and metastasis.

PPACKII is a specific and irreversible inhibitor of glandular and plasma kallikreins. Human tissue kallikreins (hKs) are a class of secreted serine proteases that involved in the release of vasodepressor peptides or kinins from a plasma substrate. Kallikreins have been implicated in many cancer-related processes, such as cell-growth regulation, angiogenesis, invasion and metastasis.

B2151 | PPACK II, trifluoroacetate DataSheet

Alternate Name/Synonyms: D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-L-phenylalaninamide, bis(trifluoroacetate); H-D-Phe-Phe-Arg-Chloromethyl Ketone

Appearance: Lyophilized solid

Formulation: N/A

CAS Number: 649748-23-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₃ClN₆O₃ • 2CF₃COOH

Molecular Weight: 729.1

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (~30 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A specific and irreversible inhibitor of glandular and plasma kallikreins

MDL Number: N/A

PubChem CID: 131698209

SMILES: C1=CC=C(C=C1)CC(C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)CCl)N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

InChi: InChI=1S/C25H33ClN6O3.2C2HF3O2/c26-16-22(33)20(12-7-13-30-25(28)29)31-24(35)21(15-18-10-5-2-6-11-18)32-23(34)19(27)14-17-8-3-1-4-9-17;2*3-2(4,5)1(6)7/h1-6,8-11,19-21H,7,12-16,27H2,(H,31,35)(H,32,34)(H4,28,29,30);2*(H,6,7)/t19-,20+,21+;;/m1../s1

InChi Key: JVMDQRDDGVKUMG-WOSURGFKSA-N