PPARγ Antagonist, G3335 | 1979

Cell-permeable. A dipeptide that acts as a selective and reversible PPARγ antagonist (KD ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀= 31.9 µM) in transfected COS-7 cells.

PPARγ Antagonist, G3335 is a dipeptide that acts as a selective and reversible PPARγ antagonist (KD ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀= 31.9 µM) in transfected COS-7 cells.

1979 | PPARγ Antagonist, G3335 DataSheet

Alternate Name/Synonyms: G3335; H-Trp-Glu-OH

Appearance: White solid

Formulation: N/A

CAS Number: 36099-95-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₉N₃O₅

Molecular Weight: 333.34

Cell-Permeable?: Yes

Purity: ≥97% by elemental analysis

Solubilities: Water

Handling: Protect from light and mositure

Country of Origin: USA

Tag Line: A selective and reversible PPARγ antagonis

MDL Number: MFCD00037964

PubChem CID: 3634442

SMILES: C1=CC=C2C(=C1)C(=CN2)CC(C(=O)NC(CCC(=O)O)C(=O)O)N

InChi: InChI=1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16 (23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23, 24)

InChi Key: PWIQCLSQVQBOQV-UHFFFAOYSA-N