Prazosin | B3055

Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs). The affinity estimates (pKi) for inhibition of [3H]-prazosin binding to CHO-K1 cells expressing cloned human α1A, α1B and α1D adrenoceptors are 9.0, 9.9 and 9.5 respectively. It also inhibits α2-ARs with Ki values of 340 nM and 3.7 nM in α2A-AR expressing HT-29 cells and α2B-AR expressing NG108 cells respectively. It is used in the treatment of hypertension, anxiety and post-traumatic stress disorder. It is in clinical trials to prevent cytokine storm in patients with COVID-19.

.Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs). The affinity estimates (pKi) for inhibition of [3H]-prazosin binding to CHO-K1 cells expressing cloned human α1A, α1B and α1D adrenoceptors are 9.0, 9.9 and 9.5 respectively. It also inhibits α2-ARs with Ki values of 340 nM and 3.7 nM in α2A-AR expressing HT-29 cells and α2B-AR expressing NG108 cells respectively. It is used in the treatment of hypertension, anxiety and post-traumatic stress disorder. It is in clinical trials to prevent cytokine storm in patients with COVID-19.

B3055 | Prazosin DataSheet

Alternate Name/Synonyms: Furazosin; [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanon

Appearance: Solid

Formulation:

CAS Number: 19216-56-9

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₉H₂₁N₅O₄

Molecular Weight: 383.4

Cell-Permeable?: TRUE

Purity: ≥95%

Solubilities: Slightly soluble in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antagonist of α1-adrenergic receptors

MDL Number: MFCD00599563

PubChem CID: 4893

SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC

InChi: InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)

InChi Key: IENZQIKPVFGBNW-UHFFFAOYSA-N