Pretomanid (PA-824) | B3033

Pretomanid is a nitroimidazopyran active againt Mycobacterium tuberculosis. It is active against multidrug-resistant M. tuberculosis clinical isolates with MIC <1 μg/ml. Pretomanid at 25, 50, and 100 mg/kg of body weight daily for 10 days or 60 days reduces the mycobacterial burden in both spleen and lung tissue in a mouse infection model. Pretomanid at 100 mg/kg in cyclodextrin/lecithin reduces the bacterial load below 500 CFU in the lungs and spleen. It is approved for use in combination treatment for drug-resistant, treatment-intolerant or non-responsive multidrug-resistant (MDR) Tuberculosis.

Pretomanid is a nitroimidazopyran active againt Mycobacterium tuberculosis. It is active against multidrug-resistant M. tuberculosis clinical isolates with MIC <1 μg/ml. Pretomanid at 25, 50, and 100 mg/kg of body weight daily for 10 days or 60 days reduces the mycobacterial burden in both spleen and lung tissue in a mouse infection model. Pretomanid at 100 mg/kg in cyclodextrin/lecithin reduces the bacterial load below 500 CFU in the lungs and spleen. It is approved for use in combination treatment for drug-resistant, treatment-intolerant or non-responsive multidrug-resistant (MDR) Tuberculosis.

B3033 | Pretomanid (PA-824) DataSheet

Alternate Name/Synonyms: (6S)-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine; (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine; (3S)-8-nitro-3-[[4-(trifluoromethoxy)phenyl]methoxy]-5-oxa-1,7-diazabicyclo[4.3.0]nona-6,8-diene

Appearance: White to Pale Yellow Solid

Formulation:

CAS Number: 187235-37-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₄H₁₂F₃N₃O₅

Molecular Weight: 359.26

Cell-Permeable?: TRUE

Purity: ≥95%

Solubilities: ~5 mg/ml in DMSO (may need warming or ultrasonication)

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A nitroimidazopyran active againt Mycobacterium tuberculosis

MDL Number: MFCD06809939

PubChem CID: 456199

SMILES: C1C(COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F

InChi: InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1

InChi Key: ZLHZLMOSPGACSZ-NSHDSACASA-N