PRI-724 | B3263

PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor of the canonical Wnt signaling pathway. PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB). Displays anticancer activity.

PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor of the canonical Wnt signaling pathway. PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB). Displays anticancer activity.

B3263 | PRI-724 DataSheet

Alternate Name/Synonyms: c-82 prodrug ICG-001 analog [4-[[(6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazin-6-yl]methyl]phenyl] dihydrogen phosphate

Appearance: Crystalline solid

Formulation:

CAS Number: 1422253-38-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₃H₃₅N₆O₇P

Molecular Weight: 658.64

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A Wnt signaling pathway inhibitor

MDL Number:

PubChem CID: 71509318

SMILES: CC1C2N(C(C(=O)N1CC3=CC=CC4=C3N=CC=C4)CC5=CC=C(C=C5)OP(=O)(O)O)C(=O)CN(N2C(=O)NCC6=CC=CC=C6)C

InChi: InChI=1S/C33H35N6O7P/c1-22-31-38(29(40)21-36(2)39(31)33(42)35-19-24-8-4-3-5-9-24)28(18-23-13-15-27(16-14-23)46-47(43,44)45)32(41)37(22)20-26-11-6-10-25-12-7-17-34-30(25)26/h3-17,22,28,31H,18-21H2,1-2H3,(H,35,42)(H2,43,44,45)/t22-,28-,31-/m0/s1

InChi Key: VHOZWHQPEJGPCC-AZXNYEMZSA-N