PRIMA-1 | 2170

A small molecule that restores tumor suppressor function to mutant p53 proteins. PRIMA-1 acts as an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.

PRIMA-1 is a small molecule that restores tumor suppressor function to mutant p53 proteins. PRIMA-1 acts as an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.

2170 | PRIMA-1 DataSheet

Alternate Name/Synonyms: 2,​2-​bis(hydroxymethyl)-​3-​quinuclidinone

Appearance: White solid

Formulation: N/A

CAS Number: 5608-24-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₉H₁₅NO₃

Molecular Weight: 185.22

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: H₂O (100 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A p53 activator

MDL Number: MFCD04974196

PubChem CID: 322968

SMILES: C1CN2CCC1C(=O)C2(CO)CO

InChi: InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2

InChi Key: RFBVBRVVOPAAFS-UHFFFAOYSA-N