PRIMA-1MET | 9485

PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 2170). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.

PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 2170). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.

9485 | PRIMA-1MET DataSheet

Alternate Name/Synonyms: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one; APR-246

Appearance: White solid

Formulation: N/A

CAS Number: 5291-32-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₀H₁₇NO₃

Molecular Weight: 199.25

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>15 mg/ml) or H₂O (>15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Mutant p53 activator

MDL Number: MFCD16294187

PubChem CID: 52918385

SMILES: COCC1(C(=O)C2CCN1CC2)CO

InChi: InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3

InChi Key: BGBNULCRKBVAKL-UHFFFAOYSA-N