PRL-3 Inhibitor | B1825

P0108 is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3) (IC₅₀ = 0.9 μM). It reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model. Sensitizes PRL-3-expressing cancer cells to chemotherapeutics. Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells.

P0108 is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3) (IC₅₀ = 0.9 μM). It reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model. Sensitizes PRL-3-expressing cancer cells to chemotherapeutics. Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells.

B1825 | PRL-3 Inhibitor DataSheet

Alternate Name/Synonyms: 5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone; P0108; BR-1; PTP4A3 Inhibitor

Appearance: Yellow solid

Formulation: N/A

CAS Number: 893449-38-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₇H₁₁Br₂NO₂S₂

Molecular Weight: 485.2

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent phosphatase of regenerating liver-3 (PRL-3) inhibitor

MDL Number: MFCD11045303

PubChem CID: 73707371

SMILES: C1=CC=C(C(=C1)COC2=C(C=C(C=C2)Br)C=C3C(=O)NC(=S)S3)Br

InChi: InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+

InChi Key: HXNBAOLVPAWYLT-OVCLIPMQSA-N