Prostratin | B2724

Prostratin is a terpenoid, non-tumorigenic PKC activator isolated from Pimelia prostrata. Induces differentiation of human myeloid leukemia cells and potentiates differentiation by chemotherapeutic agents. Inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Also, acts as a NF-κB activator. Activates HIV gene expression in T cells.

Prostratin is a terpenoid, non-tumorigenic PKC activator isolated from Pimelia prostrata. Induces differentiation of human myeloid leukemia cells and potentiates differentiation by chemotherapeutic agents. Inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Also, acts as a NF-κB activator. Activates HIV gene expression in T cells.

B2724 | Prostratin DataSheet

Alternate Name/Synonyms: (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one,CCRIS 6292,NSC 623310

Appearance: Colorless film

Formulation:

CAS Number: 60857-08-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₃₀O₆

Molecular Weight: 390.47

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A PKC activator

MDL Number: MFCD00674138

PubChem CID: 4962

SMILES: CC1CC2(C(C2(C)C)C3C1(C4C=C(C(=O)C4(CC(=C3)CO)O)C)O)OC(=O)C

InChi: InChI=1S/C22H30O6/c1-11-6-16-20(26,18(11)25)9-14(10-23)7-15-17-19(4,5)21(17,28-13(3)24)8-12(2)22(15,16)27/h6-7,12,15-17,23,26-27H,8-10H2,1-5H3

InChi Key: BOJKFRKNLSCGHY-UHFFFAOYSA-N