Proteinase 3 (PR3), Human Neutrophil | 7290

Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by alpha1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation.

7290 | Proteinase 3 PR3 Human Neutrophil DataSheet

Biomolecule/Target: AGP7

Synonyms: AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen

Alternates names: AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen

Taglines: Peptide with antibiotic and growth-promoting properties

NCBI Gene ID #: 6352

NCBI Gene Symbol: TCP228

Gene Source: Human

Accession #: P13501

Recombinant: No

Source: Human Neutrophils

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to chemoattract human blood monocytes using a concentration range of 1-10 ng/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 29 kDa

Concentration: N/A

Appearance: Frozen

Physical form description: Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1 µg/µl. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°c for future use.

Amino acid sequence: N/A