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Proteinase 3 (PR3), Human Neutrophil | 7290
- SKU:
- 26-7290-GEN
- Availability:
- Usually shipped in 5 working days
Description
Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by alpha1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation.
7290 | Proteinase 3 PR3 Human Neutrophil DataSheet
Biomolecule/Target: AGP7
Synonyms: AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen
Alternates names: AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen
Taglines: Peptide with antibiotic and growth-promoting properties
NCBI Gene ID #: 6352
NCBI Gene Symbol: TCP228
Gene Source: Human
Accession #: P13501
Recombinant: No
Source: Human Neutrophils
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: Determined by its ability to chemoattract human blood monocytes using a concentration range of 1-10 ng/ml.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 29 kDa
Concentration: N/A
Appearance: Frozen
Physical form description: Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl.
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1 µg/µl. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°c for future use.
Amino acid sequence: N/A