PS-1145 | 9671

PS-1145 is a potent and selective IκB kinase (IKK) inhibitor (IC₅₀ = 100 nM). Has no effect on PKA, PKC and CKII activity. PS-1145 efficiently inhibits both basal and induced NF-κB activity in PC cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line.

PS-1145 is a potent and selective IκB kinase (IKK) inhibitor (IC₅₀ = 100 nM). Has no effect on PKA, PKC and CKII activity. PS-1145 efficiently inhibits both basal and induced NF-κB activity in PC cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line.

9671 | PS-1145 DataSheet

Alternate Name/Synonyms: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide

Appearance: Yellow solid

Formulation: N/A

CAS Number: 431898-65-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₁ClN₄O

Molecular Weight: 322.75

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective IκB kinase (IKK) inhibitor

MDL Number: MFCD08705411

PubChem CID: 9949093

SMILES: C1=CC(=CN=C1)C(=O)NC2=C3C(=CC(=C2)Cl)C4=C(N3)C=NC=C4

InChi: InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)

InChi Key: JZRMBDHPALEPDM-UHFFFAOYSA-N