PS-341 | 1846

A potent (Ki = 0.6 nM), specific and reversible proteasome inhibitor. It inhibits cell proliferation of H460 cells (Human non-small cell lung cancer cell lines) with an IC₅₀ of 0.1 µM.

PS-341 is a potent (Ki = 0.6 nM), specific and reversible proteasome inhibitor. It inhibits cell proliferation of H460 cells (Human non-small cell lung cancer cell lines) with an IC₅₀ of 0.1 µM.

1846 | PS-341 DataSheet

Alternate Name/Synonyms: MG-341; ((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 179324-69-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₅BN₄O₄

Molecular Weight: 384.24

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (200mg/ml) or EtOH (200 mg/ml)

Handling: Protect from moisture and light

Country of Origin: USA

Tag Line: A proeasome inhibitor

MDL Number: MFCD09056737

PubChem CID: 387447

SMILES: B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

InChi: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H, 23,26)(H,24,25)/t15-,17-/m0/s1

InChi Key: GXJABQQUPOEUTA-RDJZCZTQSA-N