Quisinostat hydrochloride | B3066

Quisinostat is an inhibitor of histone deacetylase (HDAC). It shows activity toward HDAC enzymes with highest potency for recombinant HDAC1 (IC₅₀ = 0.11 nM) in vitro. The IC₅₀ values for HDAC 2 and 3 are 0.33 nM and 4.8 nM respectively. It shows broad spectrum antiproliferative activity (IC₅₀ values of 3.1-246 nM) in lung, breast, colon, prostate, brain and ovarian cancer cell lines.

Quisinostat is an inhibitor of histone deacetylase (HDAC). It shows activity toward HDAC enzymes with highest potency for recombinant HDAC1 (IC₅₀ = 0.11 nM) in vitro. The IC₅₀ values for HDAC 2 and 3 are 0.33 nM and 4.8 nM respectively. It shows broad spectrum antiproliferative activity (IC₅₀ values of 3.1-246 nM) in lung, breast, colon, prostate, brain and ovarian cancer cell lines.

B3066 | Quisinostat hydrochloride DataSheet

Alternate Name/Synonyms: N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide hydrochloride; JNJ-26481585

Appearance: Solid

Formulation:

CAS Number: 1083078-98-1

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₂₁H₂₇ClN₆O₂

Molecular Weight: 430.93

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of histone deacetylase

MDL Number:

PubChem CID: 25067557

SMILES: CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO.Cl

InChi: InChI=1S/C21H26N6O2.ClH/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29;/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28);1H

InChi Key: TWNOICNTTFKOHQ-UHFFFAOYSA-N