R-59-022 | B2975

R-59-022 is an inhibitor of Diacylglycerol (DAG) kinase with an IC₅₀ of 2.8 µM. The inhibition of Diacylglycerol kinase results in increased DAG-dependent protein kinase C (PKC) activity and potentiates aggregation of thrombin-stimulated platelets. R59022 inhibits thromboxane A(2) analogue U46619-induced contractions in mouse aorta and porcine coronary artery at concentrations of 0.1 μM to 30 μM. R-59-022 (10 µM) induces apoptosis in glioblastoma cells without being toxic to non-cancerous cells.

R-59-022 is an inhibitor of Diacylglycerol (DAG) kinase with an IC₅₀ of 2.8 µM. The inhibition of Diacylglycerol kinase results in increased DAG-dependent protein kinase C (PKC) activity and potentiates aggregation of thrombin-stimulated platelets. R59022 inhibits thromboxane A(2) analogue U46619-induced contractions in mouse aorta and porcine coronary artery at concentrations of 0.1 μM to 30 μM. R-59-022 (10 µM) induces apoptosis in glioblastoma cells without being toxic to non-cancerous cells.

B2975 | R-59-022 DataSheet

Alternate Name/Synonyms: 6-[2-[4-[(4-fluorophenyl)-phenylmethylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one; Diacylglycerol Kinase Inhibitor I

Appearance: A crystalline solid

Formulation:

CAS Number: 93076-89-2

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₇H₂₆FN₃OS

Molecular Weight: 459.58

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~5 mg/ml in ethanol and DMSO in 0, ~20 mg/ml in DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of Diacylglycerol kinase

MDL Number:

PubChem CID: 3012

SMILES: CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=CC=C4)C5=CC=C(C=C5)F)CC3

InChi: InChI=1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3

InChi Key: MFVJXLPANKSLLD-UHFFFAOYSA-N