Description
R162 is a cell-permeable, nontoxic selective inhibitor of Glutamate Dehydrogenase 1 (GDH1), (Ki = 28.6 µM) which is an upregulated enzyme in human cancers. It shows selectivity over other NADPH-dependent enzymes such as 6-phosphogluconate dehydrogenase (6PGD) and Fumarate hydratase (FH). It showes reduced levels of intracellular fumarate levels and Glutathione peroxidase (GPx) activity with increase in mitochondrial ROS levels. Decreases the tumor growth and inhibits the cancer cell proliferation of H1299 and primary leukemia cells.
R162 is a cell-permeable, nontoxic selective inhibitor of Glutamate Dehydrogenase 1 (GDH1), (Ki = 28.6 µM) which is an upregulated enzyme in human cancers. It shows selectivity over other NADPH-dependent enzymes such as 6-phosphogluconate dehydrogenase (6PGD) and Fumarate hydratase (FH). It shows reduced levels of intracellular fumarate levels and Glutathione peroxidase (GPx) activity with increase in mitochondrial ROS levels. Decreases the tumor growth and inhibits the cancer cell proliferation of H1299 and primary leukemia cells.
Alternate Name/Synonyms: 1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
Appearance: Orange solid
Formulation: N/A
CAS Number: 64302-87-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₇H₁₂O₃
Molecular Weight: 264.28
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (>10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A Glutamate Dehydrogenase 1 (GDH1) inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C1C2=C(C=CC=C2)C(C3=CC=C(CC=C)C(O)=C13)=O
InChi: InChI=1S/C17H12O3/c1-2-5-10-8-9-13-14(15(10)18)17(20)12-7-4-3-6-11(12)16(13)19/h2-4,6-9,18H,1,5H2
InChi Key: IMUBGIOLZQTIGI-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |