R162 | B1180

R162 is a cell-permeable, nontoxic selective inhibitor of Glutamate Dehydrogenase 1 (GDH1), (Ki = 28.6 µM) which is an upregulated enzyme in human cancers. It shows selectivity over other NADPH-dependent enzymes such as 6-phosphogluconate dehydrogenase (6PGD) and Fumarate hydratase (FH). It showes reduced levels of intracellular fumarate levels and Glutathione peroxidase (GPx) activity with increase in mitochondrial ROS levels. Decreases the tumor growth and inhibits the cancer cell proliferation of H1299 and primary leukemia cells.

R162 is a cell-permeable, nontoxic selective inhibitor of Glutamate Dehydrogenase 1 (GDH1), (Ki = 28.6 µM) which is an upregulated enzyme in human cancers. It shows selectivity over other NADPH-dependent enzymes such as 6-phosphogluconate dehydrogenase (6PGD) and Fumarate hydratase (FH). It shows reduced levels of intracellular fumarate levels and Glutathione peroxidase (GPx) activity with increase in mitochondrial ROS levels. Decreases the tumor growth and inhibits the cancer cell proliferation of H1299 and primary leukemia cells.

B1180 | R162 DataSheet

Alternate Name/Synonyms: 1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione

Appearance: Orange solid

Formulation: N/A

CAS Number: 64302-87-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₇H₁₂O₃

Molecular Weight: 264.28

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Glutamate Dehydrogenase 1 (GDH1) inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C1C2=C(C=CC=C2)C(C3=CC=C(CC=C)C(O)=C13)=O

InChi: InChI=1S/C17H12O3/c1-2-5-10-8-9-13-14(15(10)18)17(20)12-7-4-3-6-11(12)16(13)19/h2-4,6-9,18H,1,5H2

InChi Key: IMUBGIOLZQTIGI-UHFFFAOYSA-N