R428 | 9591

R428 is a potent and selective small-molecule inhibitor (IC₅₀ = 14 nM) of the receptor tyrosine kinase Axl. R428 blocks Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production.

R428 is a potent and selective small-molecule inhibitor (IC₅₀ = 14 nM) of the receptor tyrosine kinase Axl. R428 blocks Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production.

9591 | R428 DataSheet

Alternate Name/Synonyms: 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine;BGB324

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1037624-75-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₃₄N₈

Molecular Weight: 506.64

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective AXL kinase Inhibitor

MDL Number: N/A

PubChem CID: 46215462

SMILES: C1CCN(C1)C2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76

InChi: InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1

InChi Key: KXMZDGSRSGHMMK-VWLOTQADSA-N