RAF265 | 2856

RAF265 (CHIR-265) is a potent and selective inhibitor of C-Raf/B-Raf/B-Raf V600E (IC₅₀ of 3-60 nM); displays potent inhibition on VEGFR2 phosphorylation with EC₅₀ of 30 nM. RAF265 inhibits the growth of advanced human melanoma tumors.

RAF265 (CHIR-265) is a potent and selective inhibitor of C-Raf/B-Raf/B-Raf V600E (IC₅₀ of 3-60 nM); displays potent inhibition on VEGFR2 phosphorylation with EC₅₀ of 30 nM. RAF265 inhibits the growth of advanced human melanoma tumors.

2856 | RAF265 DataSheet

Alternate Name/Synonyms: 1-Methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine; CHIR265

Appearance: Light yellow to yellow solid

Formulation: N/A

CAS Number: 927880-90-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₁₆F₆N₆O

Molecular Weight: 518.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>100 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective inhibitor of C-Raf/B-Raf/B-Raf V600E

MDL Number: N/A

PubChem CID: 11656518

SMILES: CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F

InChi: InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)

InChi Key: YABJJWZLRMPFSI-UHFFFAOYSA-N