Description
RAF265 (CHIR-265) is a potent and selective inhibitor of C-Raf/B-Raf/B-Raf V600E (IC₅₀ of 3-60 nM); displays potent inhibition on VEGFR2 phosphorylation with EC₅₀ of 30 nM. RAF265 inhibits the growth of advanced human melanoma tumors.
RAF265 (CHIR-265) is a potent and selective inhibitor of C-Raf/B-Raf/B-Raf V600E (IC₅₀ of 3-60 nM); displays potent inhibition on VEGFR2 phosphorylation with EC₅₀ of 30 nM. RAF265 inhibits the growth of advanced human melanoma tumors.
Alternate Name/Synonyms: 1-Methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine; CHIR265
Appearance: Light yellow to yellow solid
Formulation: N/A
CAS Number: 927880-90-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₁₆F₆N₆O
Molecular Weight: 518.41
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>100 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective inhibitor of C-Raf/B-Raf/B-Raf V600E
MDL Number: N/A
PubChem CID: 11656518
SMILES: CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F
InChi: InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
InChi Key: YABJJWZLRMPFSI-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |