Description
A DNA methyltransferase (DNMT) inhibitor. RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In combination with BIX 01294 (Cat. No. 1678-5), RG 108 enhances reprogramming.
RG 108 is a DNA methyltransferase (DNMT) inhibitor. RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences.
Alternate Name/Synonyms: N-Phthalyl-L-tryptophan
Appearance: Beige to yelllow solid
Formulation: N/A
CAS Number: 48208-26-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₄N₂O₄
Molecular Weight: 334.33
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (10 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A DNA methyltransferase (DNMT) inhibitor
MDL Number: N/A
PubChem CID: 702558
SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)C(CC3=CNC4=CC=CC=C43)C(=O)O
InChi: InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)/t16-/m0/s1
InChi Key: HPTXLHAHLXOAKV-INIZCTEOSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |